早期乙型肝炎肝硬化中医证素特征及其与血浆CTGF、PDGF的相关性研究  

Correlation of Traditional Chinese Medical Syndrome Elements with Plasma Connective Tissue Growth Factor and Platelet-derived Growth Factor in Early Liver Cirrhosis Induced by Type B Hepatitis

作　　者：刘瑶[1] 吴同玉[1] 李东良[2] 沈建英[1] 张凌媛[1] 丁珊珊[1] 石志平[1] 陈湘筠 

机构地区：[1]福建中医药大学,福建福州350122 [2]南京军区福州总医院,福建福州350025

出　　处：《广州中医药大学学报》2015年第1期4-9,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金项目(编号:81102559)

摘　　要：【目的】探讨早期乙型肝炎肝硬化的证素特征及其与血浆结缔组织生长因子(connective tissue growth factor,CTGF)、血小板衍生生长因子(platelet-derived growth factor,PDGF)的相关性。【方法】运用中医证素辨证方法判断早期乙型肝炎肝硬化的中医病理特征,同时运用酶联免疫吸附法(ELISA)测定血浆CTGF、PDGF的含量,并判断其相关性。【结果】(1)早期乙型肝炎肝硬化患者的证素特征:病位证素主要是肝、脾,病性证素主要是湿、热、气滞、阴虚;(2)CTGF与脾、胆、湿证素密切相关(OR值分别为1.598、1.567、2.797>1),PDGF与热证素密切相关(OR=1.134>1)。【结论】早期乙型肝炎肝硬化的发生发展以肝和脾为主要病发部位,湿、热、气滞和阴虚是其重要的病理属性。CTGF值越高,越容易出现脾、胆、湿的病理变化,说明肝纤维化程度越重,病位越容易涉及脾、胆,病性证素湿也较容易出现在早期乙型肝炎肝硬化患者中;PDGF值越高时,热的病理变化较容易出现,热证素也较容易出现在早期乙型肝炎肝硬化患者中。Objective To explore the correlation of traditional Chinese medical syndrome elements with plasma＆nbsp;connective tissue growth factor （ CTGF） and platelet-derived growth factor （ PDGF） in early liver cirrhosis induced by type B hepatitis. Methods The distribution of traditional Chinese medical syndrome elements in early liver cirrhosis induced by type B hepatitis was analyzed, plasma contents of CTGF and PDGF were detected by enzyme-linked immunosorbent assay （ ELISA） , and the correlation of syndrome elements with CTGF and PDGF was discriminated. Results （ 1） The distribution of traditional Chinese medical syndrome elements in early liver cirrhosis induced by type B hepatitis showed as follows： the syndrome elements involved the viscera of liver and spleen, and the pathogenesis was characterized as dampness, heat, qi stagnation, and yin deficiency. （ 2） CTGF was closely related with spleen, gallbladder and dampness, with OR value being 1.598, 1.567, 2.797, respectively. PDGF was closely related with heat, with OR value being 1.134. Conclusion Early liver cirrhosis induced by type B hepatitis mainly affects the viscera of liver and spleen, the pathogenesis is characterized by dampness, heat, qi stagnation, and yin deficiency. The patients with higher CTGF are apt to show the pathological changes of spleen, gallbladder, dampness, and have the syndrome el-ements of spleen, gallbladder, dampness. The patients with higher PDGF are apt to show the pathological changes of heat, and have the syndrome element of heat.

关 键 词：乙型肝炎肝硬化 证素 结缔组织生长因子 血小板衍生生长因子 

分 类 号：R575.2[医药卫生—消化系统]