丙泊酚全麻对乳腺癌术后复发的影响研究  

The Effect of General Anesthesia with Propofol on Postoperative Recurrence in Breast Cancer

作　　者：黄柯冰 袁磊[1] 黄杰[1] 李凤仙[1] 

机构地区：[1]陕西省汉中市中心医院,陕西汉中723000

出　　处：《中国伤残医学》2015年第3期12-14,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：探讨利用丙泊酚实施全麻对乳腺癌患者复发的影响。方法：选取在我院治疗的40例I-II期的乳腺癌患者， ASAI－II级，所有患者行全麻手术，观察手术前后的血管生成因子VEGF－C、bFGF、PIGF及TGFβ的变化，并选择同期体检的40例健康人群作为正常对照。结果：VEGF－C和PIGF较术前显著上升（ P＜0．05），而bFGF和TGFβ则降低（ P＜0．05），但仍然高于正常对照组；同时手术前后VEGF－C和bFGF的差值与P／W成正相关，而TGFβ的差值与P／W却成负相关。结论：利用不同剂量的丙泊酚对乳腺癌患者实施全麻后会对各个血管生成因子变化的成不同程度的影响，从而影响肿瘤的复发；因此，寻找最佳的丙泊酚剂量实施全麻具有十分重要的临床意义。Objective：To explore the use of propofol effect implementation of general anesthesia in patients with breast cancer recur -rence.Method：Select 40 cases of I-II of breast cancer patients in our hospital for treatment , ASA I-II-level, all patients with General anesthesia and surgery , observing the change of angiogenesis factor before and after operation , including VEGF -C, bFGF, TGFβand PIGF, and select the same period medical examination 40 healthy people as the normal controls. Results：VEGF-C and PIGF preoperative increased significantly （P〈0.05）, bFGF, TGFβreduced （P〈0.05）, but still higher than normal control groups;and there were posi-tive correlation between P/W and VEGF-C and bFGF, and TGFβand P/W had negative correlation. Conclusion：The use of different do-ses of propofol in breast cancer patients after general anesthesia had different levels of impact on various angiogenesis factors , thus affecting the recurrence of tumors , so look for the best implementation of general anesthesia of propofol dose of great clinical was significance.

关 键 词：丙泊酚 乳腺癌 血管生成因子 

分 类 号：R737.9[医药卫生—肿瘤]