鼻咽癌患者治疗前外周血Th_1细胞因子浓度与远期生存的关系  

Serum Th_1 cytokine levels and long-term survival of patients with nasopharyngeal carcinoma

作　　者：冯星来[1] 陈晓钟[1] 

机构地区：[1]浙江省肿瘤医院放疗科,杭州310022

出　　处：《浙江医学》2014年第24期1993-1996,共4页Zhejiang Medical Journal

摘　　要：目的评价治疗前血清Th_1细胞因子(IL-2、TNF-α和IFN-γ)浓度在鼻咽癌放化疗中对患者远期生存的影响。方法使用流式细胞小球微阵列术检测80例鼻咽癌患者治疗前血清Th_1细胞因子水平,使用Kaplan-Meier法绘制生存曲线,使用COX回归法分析细胞因子水平与患者总生存(OS)之间的关系。结果非角化性鼻咽癌上IFN-γ水平较角化性癌升高(P=0.012);Th_1细胞因子水平与患者放化疗治疗效果差异无统计学意义(P>0.05),治疗前TNF-α高浓度组患者预后明显不如低浓度组(P=0.015),治疗前IL-2高浓度组患者预后明显好于低浓度组(P=0.048)。结论鼻咽癌患者治疗前TNF-α及IL-2水平是预后的独立预测因素。Objective To investigate the correlation of serum Th1 cytokine levels with long- term survival of patients with nasopharyngeal carcinoma（NPC）. Methods Pretreatment serum Th1 cytokines IFN- γ, TNF- αand IL- 2 were detected by cy-tometric bead array（CBA） method in 80 NPC patients undergoing chemoradiotherapy. The survival of patients was measured by Kaplan- Meier curve. The association between cytokine levels and the overal survival （OS） of patients were evaluated with Cox regression analysis. Results Serum IFN- γ levels in patients with non- keratinizing carcinoma were higher than that with kera-tinizing carcinoma （P=0.012）. The pretreatment serum IFN- γ, TNF- α and IL- 2 levels were not significantly correlated with treatment response （P〉0.05） adjusted for age, gender, TNM stage and tumor cel histology of patients. Higher pretreatment serum TNF- α levels were significantly associated with poorer survival （P =0.015）. Patients with a higher pretreatment serum IL- 2 levels had a significantly longer survival than patients with lower levels（P=0.048）. Conclusion High serum TNF- level and low IL- 2 level may predict unfavorable prognosis in patients with NPC.

关 键 词：鼻咽癌 细胞因子 预后 放化疗 

分 类 号：R739.63[医药卫生—肿瘤]