COX-2和Survivin在人成釉细胞瘤中的表达及其意义研究  

Expression of COX-2 and Survivin in ameloblastoma and its clinical significance

作　　者：李乐[1] 张兴乐[1] 王鹏[1] 刘雨[2] 

机构地区：[1]承德医学院附属医院口腔科,河北承德067000 [2]承德医学院附属医院手术部,河北承德067000

出　　处：《中国实用口腔科杂志》2014年第12期744-746,共3页Chinese Journal of Practical Stomatology

基　　金：承德市科学技术研究与发展计划项目(201121054)

摘　　要：目的探讨COX-2和Survivin在人成釉细胞瘤(ameloblastoma,AB)中的表达及意义。方法收集2010年3月至2012年10月在承德医学院附属医院口腔科行手术治疗的20例AB患者的肿瘤组织标本以及20例唇裂患者的正常唇红黏膜组织标本,采用蛋白质印记法(Western Blot)检测其中COX-2和Survivin的表达。采用SPSS19.0统计软件对数据进行分析。结果 AB中COX-2和Survivin的表达明显高于正常口腔黏膜,差异有统计学意义(P<0.05),且COX-2和Survivin的表达呈正相关(r=0.778,P<0.05)。结论 COX-2和Survivin在AB中高表达,呈现一致性,且明显高于正常口腔黏膜;COX-2和Survivin可能与AB的发生发展有关。Objective To study the expression of cyclooxygenase-2（COX-2）and Survivin in ameloblastoma（AB）tissues and its clinical significance.MethodsDetect the expression of COX-2 and Survivin by Western Blot method from20 cases suffering from AB and 20 cases of normal oral mucosa.ResultsThe expression of COX-2 and Survivin in ameloblastoma tissues was significantly higher than those in normal oral mucosa tissues（P〈0.05）. The high expression of COX-2 was positively correlated with the positive expression of Survivin at the same time（r = 0.778,P〈0.05）.ConclusionCOX-2 and Survivin are overexpressed in the AB,and they express slight in the normal oral mucosas. The results suggest that the overexpression of COX-2 and Survivin in human ameloblastoma is closely correlated. COX-2 and Survivin get involved in the occurrence and development of the AB.

关 键 词：成釉细胞瘤 COX-2 SURVIVIN 蛋白质印记法 

分 类 号：R78[医药卫生—口腔医学]