Preparation of ^(188)Re-HEDP lyophilized kit for instant bone metastases therapy  

作　　者：杨志 朱华 李囡 马云霞 张岩 

机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),Department of Nuclear Medicine, Peking University Cancer Hospital & Institute

出　　处：《Nuclear Science and Techniques》2014年第6期48-53,共6页核技术（英文）

基　　金：Supported by the National Natural Science Foundation of China(Nos.81071198,81172083 and 81371592);Beijing Natural Science Foundation(No.7132040)

摘　　要：Hydroxyethylidene diphosphonate(HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of188Re-HEDP.188Re-HEDP showed high focile uptake in normal mice(> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed tomography(SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.Hydroxyethylidene diphosphonate（HEDP） was prepared and labeled with rhenium-188. Its lyophilized kit was developed for instant preparing of ^188Re-HEDP.^188Re-HEDP showed high focile uptake in normal mice（〉 30% ID/g at carrier co-injection） in BABLC/SPF mice. High quality single photon emission computed tomography（SPECT） image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74 MBq radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone metastases therapy.

关 键 词：试剂盒 冻干 制备 治疗 即时 放射性示踪剂 HEDP 静脉注射 

分 类 号：R738.1[医药卫生—肿瘤]