直肠应用吲哚美辛在预防ERCP术后胰腺炎中作用的研究  

RECTAL INDOMETHACIN FOR PREVENTION OF POST-ERCP PANCREATITIS

作　　者：季涛[1] 孙洪艾 王翠江[1] 谭洪武[1] 徐向明[1] 杨静[1] 

机构地区：[1]临沂市人民医院消化一科,山东临沂276003 [2]临沂市红十字会中心血站

出　　处：《山东医学高等专科学校学报》2014年第6期415-417,共3页Journal of Shandong Medical College

基　　金：临沂市科技发展计划项目(No.201413003)

摘　　要：目的观察直肠应用吲哚美辛对ERCP术后胰腺炎(PEP)及高淀粉酶血症的预防作用。方法将行ERCP检查的260例患者随机分为吲哚美辛组和对照组,吲哚美辛组在ERCP术前60min直肠内给予吲哚美辛栓剂100mg,对照组在ERCP术前不予直肠内治疗。观察ERCP术后患者有无腹痛,并于术后4、24、48h做血清淀粉酶测定。结果吲哚美辛组PEP发生率(6.9%)与对照组PEP发生率(22.3%)有统计学差异(P<0.05),吲哚美辛组ERCP术后高淀粉酶血症发生率(20.8%)显著低于对照组(52.3%,P<0.05)。结论直肠应用吲哚美辛可以预防ERCP术后胰腺炎(PEP)和高淀粉酶血症的发生。Objective To investigate the effect of prophylactic rectal indomethacin on post-ERCP hyperamylasemia and pancreatitis.Methods 260 patients who underwent ERCP for various reasons were randomly divided into the indomethacin group and the contrast group.Rectal indomethacin（100mg）was administered to indomethacin group prior to ERCP.Serum amylase level was measured 4,24,48 hours after operation.Results The incidence of post-ERCP pancreatitis（PEP）was 6.9% in the indomethacin groupand 22.3% in the control group（P〈0.05）.The incidence of post-ERCP hyperamylasemia was 20.8%in the indomethacin group and 52.3%in the control group（P〈0.05）.Conclusion Rectal indomethacin can prevent PEP and hyperamylasemia induced by ERCP.

关 键 词：内窥镜逆行性胰胆管造影术 胰腺炎 吲哚美辛 

分 类 号：R576[医药卫生—消化系统]