HPV L1壳蛋白在新疆汉族和维吾尔族HPV阳性妇女中的表达  

Expression of HPV L1 capsid protein in cervical exfoliated cells from Han and Uygur nationality women with HPV infection in Xinjiang

作　　者：赵丽霞[1] 耿文[1] 玛依努尔.尼亚孜 亚力坤.穆罕默德 

机构地区：[1]新疆维吾尔自治区人民医院,新疆乌鲁木齐830001 [2]新疆医科大学附属肿瘤医院,新疆乌鲁木齐830001

出　　处：《中国热带医学》2014年第12期1423-1425,1439,共4页China Tropical Medicine

基　　金：国家自然科学基金(No.81160317)

摘　　要：目的探讨新疆汉族、维吾尔族人乳头瘤病毒(HPV)阳性妇女宫颈脱落细胞中HPV L1壳蛋白的不同表达。方法对221例HPV阳性的汉族妇女、178例维吾尔族妇女采用液基细胞学检查,在宫颈脱落细胞标本中,检测HPV L1壳蛋白的不同表达。结果汉族HPV L1壳蛋白在正常宫颈细胞(NILM)、非典型磷状上皮细胞(ASC-US)、低度鳞状上皮内瘤变(LSIL)、高度鳞状上皮内瘤变(HSIL)和鳞状细胞癌(SCC)的阳性表达率分别为39.19%、42.86%、64.71%、14.29%和0,≥LSIL病变中,两两比较差异有统计学意义(P<0.05)。维吾尔族阳性表达率分别为33.33%、37.24%、53.66%、0和0,在ASC-US、LSIL、HSIL组中,两两比较差异有统计学意义(P<0.05),HSIL、SCC两组无表达。两民族中,同级别病变比较差异无统计学意义(P>0.05)。在组织病理学诊断中,两民族同级别比较差异无统计学意义(P>0.05)。≥CINI病变中,两民族均随病变加重HPV L1壳蛋白阳性率降低,差异有统计学意义(P<0.05)。结论汉族、维吾尔族HPV L1壳蛋白在同级别病变中表达差异无统计学意义,在不同病变中其差异均随病变程度加重而降低。Objective To investigate the expression of HPV L1 capsid protein in cervical exfoliated cells from Han and Uygur nationality women with HPV infection in Xinjiang. Methods The expression of HPV L1 capsid protein in cervical exfoliated cells from 221 Hart and 178 Uygur women with HPV infection was detected by liquid based cytology. Results The expression rates of HPV L1 capsid protein in normal cervical cells （NILM）, atypical phosphorus epithelial cells （ASC - US）, low-grade squamous intraepithelial neoplasma （LSIL）, highly squamous intraepithelial neoplasma （HSIL） and squamous cell carcinoma （SCC） in Han women were 39.19%, 42.86%, 64.71%, 14.29% and 0, respectively,revealed statistically significant differences between LSIL and HSIL, LSIL and SCC, HSIL and SCC groups （P 〈0.05）. The expression rates of HPV L1 capsid protein in NILM, ASC - US, LSIL, HSIL and SCC in Uygur women were 33.33%, 37.24%, 53.66%, 0 and 0, respectively also exhibited statistically significant differences （P 〈0.05） between ASC-US and LSIL, ASC-US and H$IL, LSIL and HSIL groups, but without expression in HSIL and SCC groups. HPV L1 capsid protein was not expressed in two ethnic groups with the same level of the lesions （P 〉0.05） by biopsy. The expression rate of HPV L1 capsid protein was reduced with the aggravation of the lesions （-CINI） showing significant differences （P 〈0.05） between the two nations. Conclusion The expression rate of HPV L1 capsid protein showed no statistical significance between Han and Uygur nationality women infected with HPVL1 at the same level of lesions and it was reduced with the increase of aggravation in different levels of lesions.

关 键 词：液基细胞学 HPV L1壳蛋白 汉族 维吾尔族 

分 类 号：R737.33[医药卫生—肿瘤]