壳聚糖改性山梨酸壳聚糖酯的工艺条件研究  

Study on Conditions for Modifying Chitosan Into Sorbic Acid Chitosan Ester

作　　者：徐祥浩[1] 李和生[1] 刘漫[1] 邓月[1] 

机构地区：[1]宁波大学海洋学院,浙江宁波315211

出　　处：《核农学报》2014年第12期2223-2229,共7页Journal of Nuclear Agricultural Sciences

基　　金：浙江省重大科技专项(2009C03017-3);宁波市自然科学基金项目(2013A610156);"水产"浙江省重中之重学科开放基金项目(xkzsc1426)

摘　　要：以壳聚糖和山梨酰氯为主要原料,以山梨酸壳聚糖酯得率为指标,运用酰氯法研究山梨酸壳聚糖酯的制备工艺,在单因素试验基础上,以反应时间、反应温度、山梨酰氯与氨基葡萄糖残基摩尔比3个因素,运用三因素三水平响应面分析法优化山梨酸壳聚糖酯的制备工艺。响应面优化结果表明,山梨酸壳聚糖酯的最佳制备工艺条件为:反应时间3.11h,反应温度30.04℃,山梨酰氯与氨基葡萄糖残基摩尔比2.92∶1,山梨酸壳聚糖酯的得率可达61.7%。验证试验中产物得率为57.4%,表明验证试验结果与理论模型预测结果相符。这为低成本、规模化合成壳聚糖山梨酸酯提供基础研究数据,为壳聚糖的应用开拓一条新的途径。With chitosan and sorbic acid chloride as the main material,with sorbic acid chitosan ester yield as the indicators. The preparation of sorbic acid chitosan ester by chloride method was researched. Based on the single-factor test,optimization model of sorbic acid chitosan ester was established. The response surface optimization results of sorbic acid chitosan ester were determined as following： reaction time 3. 11 h,reaction temperature 30. 04℃,reactant ratios2. 92： 1. Under this condition,the experimental yield of sorbic acid chitosan ester was up to 61. 7%. In the verification test,the yield of the products was 57. 4%,in close agreement with the predicted value.

关 键 词：壳聚糖 山梨酰氯 山梨酸壳聚糖酯 响应面法 

分 类 号：TS202.3[轻工技术与工程—食品科学]