Eph受体酪氨酸激酶A2和CD133在胃癌组织的表达及其与胃癌发生发展的关系  

Expression of erythropoietin producing human hepatocellular receptor A2 and CD133 in gastric carcinoma and their correlation with development of gastric cancer

作　　者：叶石才[1] 孙碧兰 黄昕[2] 吴巍芸[1] 徐飞鹏[3] 林琳[3] 

机构地区：[1]广东医学院附属医院消化内科,广东湛江524001 [2]广东医学院附属医院肿瘤中心,广东湛江524001 [3]广东医学院附属医院普外科,广东湛江524001

出　　处：《中华实验外科杂志》2015年第1期165-167,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨Eph受体酪氨酸激酶A2（EphA2）和CD133在胃癌组织中的表达及其与临床病理特征和预后关系.方法 采用免疫组织化学法检测82例胃癌患者手术切除的癌组织和癌旁组织中EphA2和CD133表达水平.结果 EphA2在胃癌组织中的表达率明显高于癌旁组织（86.59％比20.73％,P＜0.01）,CD133在胃癌组织中的表达率明显高于癌旁组织（67.07％比10.98％,P＜0.01）;EphA2表达水平与胃癌TNM分期、淋巴结转移明显相关（P＜0.05）,CD133表达水平与胃癌组织学分化程度、TNM分期、淋巴结转移明显相关（P＜0.05）.结论 EphA2和CD133过度表达可能在胃癌的发生、发展过程中发挥作用.Objective To analyze the expression of erythropoietin producing human hepatocellular receptor A2 （EphA2） and CD133 in gastric carcinoma and their relationship with clinicopathological features and the prognosis of gastric carcinoma.Methods Envision immunohistochemical method was used to assess the expression of EphA2 and CD133 in 82 cases of human gastric carcinoma tissues and non-cancerous adjacent gastric tissues.Results The expression rate of EphA2 in gastric carcinoma tissues was higher than that in non-cancerous adjacent gastric tissues （86.59% vs.20.73%,P 〈 0.01）.The expression rate of CD133 in gastric carcinoma tissues was higher than that in non-cancerous adjacent gastric tissues （67.07% vs.10.98%,P 〈0.01）.The expression of EphA2 was related to TNM stage and lymph node metastasis of gastric carcinoma （P 〈 0.05）.There was a close correlation between the expression of CD133 and histological grade,TNM stage and lymph node metastasis （P 〈 0.05）.Conclusion The overexpression of EphA2 and CD133 may play certain roles in the pathogenesis of gastric carcinoma.

关 键 词：胃癌 Eph受体酪氨酸激酶A2 CD133 免疫组织化学法 

分 类 号：R735.2[医药卫生—肿瘤]