细胞核增殖抗原与E-钙黏蛋白在膀胱移行细胞癌中的表达及临床意义  

The expression and significance of Ki-67 and E-cadherin in bladde transitional cell carcinoma

作　　者：徐卫波[1] 侯俊清[1] 刘广超[2] 杜信毅[1] 李铁强[1] 朱朝阳[1] 

机构地区：[1]河南大学淮河医院泌尿外科,开封475000 [2]河南大学抗体药物河南省工程实验室

出　　处：《中华实验外科杂志》2015年第1期185-186,共2页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨细胞核增殖抗原（Ki-67）、E-钙黏蛋白（E-cadherin）在膀胱移行细胞癌中的表达及其临床意义.方法 采用免疫组织化学方法检测Ki-67、E-cadherin在48例膀胱移行细胞癌组织中的表达,统计分析其表达与膀胱移行细胞癌临床病理、分期之间的关系.结果 Ki-67、E-cadherin在膀胱移行细胞癌中的阳性表达率分别是83.3％和47.9％,两者呈负相关（P＜0.05）.两者表达水平与肿瘤临床分期及病理分级明显相关（P＜0.05）.结论 检测Ki-67与E-cadherin有助于判断膀胱移行细胞癌侵袭和转移能力.Objective To explore the clinical significance and expression of proliferation cell nuclear antigen （Ki-67） and E-cadherin in bladder transitional cell carcinoma.Methods Immunohistochemistry was applied to detect the expression of Ki-67 and E-cadherin in 48 cases of bladder transitional cell carcinoma,and the relationship between their expression and clinicopathological features was analyzed.Results The expression of Ki-67 and E-cadherin was negatively correlated （P 〈 0.05）,and their positive rate was 83.3% and 47.9% respectively.They were related to tumor pathological grade and clinical stage.Conclusion Detection of Ki-67 and E-cadherin will help determine the invasion and metastasis ability of bladder transitional cell carcinoma.

关 键 词：膀胱移行细胞癌 细胞核增殖抗原 E-钙黏蛋白 

分 类 号：R737.14[医药卫生—肿瘤]