非小细胞肺癌并肺寡转移的外科治疗  

Surgical treatment for primary non-small cell lung cancer with pulmonary oligometastasis

作　　者：何锦园[1] 李昀[1] 刘立宝[1] 黄邵洪[1] 张军航[1] 

机构地区：[1]中山大学附属第三医院心胸外科,广州市510630

出　　处：《实用医学杂志》2015年第1期76-78,共3页The Journal of Practical Medicine

摘　　要：目的:探讨局部手术对非小细胞肺癌(NSCLC)肺寡转移患者的生存影响。方法:回顾分析我院2003年1月至2013年12月确诊为原发性NSCLC肺寡转移病例共21例,分两组,A组为手术组,共11例,男6例,女5例,中位年龄55岁;B组为化疗组,共10例,男6例,女4例,中位年龄60岁,比较两组患者中位生存期(MST)及5年生存率的差异,以及A组患者中原发灶TNM、p N分期、转移模式、结节数对生存期的影响。结果:两组MST分别为37个月和11.6个月,5年生存率分别为18.2%和9.1%(P<0.05);A组中单发、异时性转移、原发灶为p N0、Ⅰ和Ⅱ期的患者总生存期高于多发、同时性转移、原发灶为p N1-2、Ⅲ和Ⅳ期者(P<0.05)。结论:局部手术治疗能明显延长NSCLC肺寡转移患者的生存期和5年生存率。Objective To investigate the effect of local surgery on survival in patients with non-small cell lung cancer complicated by pulmonary oligometastasis. Methods We retrospectively studied 21 patients with primary non-small cell lung cancer complicated by pulmonary oligometastasis diagnosed from January 2003 to December 2013. The patients were divided into two groups： group A （11 patients） underwent surgery, and group B（10 patients） received systematic chemotherapy. We compared median survival time （MST） and 5-year survival rate between the two groups, and analyzed the impact of TNM and pN stage of primary tumor, metastasis mode, and number of oligometastatic nodules on the survival in group A. Results MST was 37 months in group A and 11.6 months in group B, and 5-year survival rate was 18.2% and 9.1% respectively （P 〈 0.05）. Patients with single nodule, metachronous metastases, pN0, or TNM stage Ⅰ or Ⅱ had a higher survival rate than those with multiple nodules, simultaneous metastases, pN1-2, or stage Ⅲ or Ⅳ in group A （P 〈 0.05）. Conclusions Local surgical treatment can significantly prolong the overal survival time and 5-year survival rate in patients with primary non- small cell lung cancer complicated by pulmonary oligometastasis.

关 键 词：肺癌 非小细胞 寡转移 异时性转移 同时性转移 

分 类 号：R734.2[医药卫生—肿瘤]