ABCB1基因位点(C3435T)多态性与癫痫耐药关联性的Meta分析  

Meta analysis of relationship between polymorphism of gene site (C3435T) of ABCB1 and antiepileptic drug resistant

作　　者：彭锐[1] 张洪[1] 张英[1] 魏丹芸 

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060

出　　处：《中国医药导报》2015年第2期69-73,共5页China Medical Herald

摘　　要：目的探讨ABCB1的基因位点(C3435T)多态性与癫痫耐药关联性。方法计算机检索Pubmed、Science direct、Wiley online library、Web of Science、中国知网、万方数据库和维普中文科技期刊数据库,纳入抗癫痫药耐药与抗癫痫药敏感的随机对照试验,同时查阅检索结果中所附相似文献及参考文献,检索文献均为建库至2014年6月15日。由两名评价员单独进行文献筛选及资料提取,采用Rev Man 5.0软件进行Meta分析及其他统计学分析。结果共纳入文献10篇,癫痫患者中耐药815例,敏感976例。Meta分析结果显示,C3435T位点多态性在等位基因模型、显性模型、隐性模型、共显性模型(CC/TT组)下整体效应差异有统计学意义(P<0.05):等位基因模型OR=0.79,95%CI(0.69,0.90),显性基因模型OR=0.73,95%CI(0.58,0.92),隐性基因模型OR=0.73,95%CI(0.59,0.91),共显性基因模型(CC/TT组)OR=0.64,95%CI(0.48,0.85)。地区亚组分析结果显示,中国地区ABCB1 C3435T位点基因多态性与癫痫耐药差异均无统计学意义(P>0.05);而印度地区ABCB1 C3435T位点基因多态性与癫痫耐药在等位基因模型和隐性基因模型下整体效应差异有统计学意义(P<0.05):等位基因模型OR=0.70,95%CI(0.54,0.93),隐性基因模型OR=0.72,95%CI(0.49,1.07)。结论 ABCB1 C3435T位点基因多态性与中国地区癫痫耐药无相关性,而在印度地区人口中与癫痫耐药有相关性。Objective To investigate the association between C3435T site polymorphism of ABCB1 gene with antiepileptic drug resistant. Methods Computer was used to retrieve articles from the Pubmed, Science direct, Wiley online library, Web of Science,CNKI, CDDB database and VIP. The articles were searched and sorted out which were drug-resistant/drug-responsive study about the association between ABCB1 gene loci polymorphism with antiepileptic drug resistant, also combined with manually retrieving the references and similar results in the attached documents. The range of searching time was all from inception to June 15, 2014. Literature screening and data extracting were handled by two reviews independently. RevMan 5.0 software was used to conduct the Meta-analysis and other statistic analysis. Results 10 articles were included in the research. It showed that the total number of patients with drug-resistant were 815 cases, and the total number of patients with drug-responsive were 976 cases. While the Meta-analysis results showed that there existed significant correlations between ABCB1 C3435T loci polymorphism and antiepileptic drug re-sistant in the allele gene model, dominant gene model, recessive gene model and co-dominant gene model（CC/TT） （P〈0.05）：the allele gene model, OR=0.79, 95%CI （0.69, 0.90）;dominant gene model, OR=0.73, 95%CI （0.58, 0.92）; reces-sive gene model, OR=0.73, 95%CI （0.59, 0.91）; co-dominant gene model （CC/TT）, OR=0.64, 95%CI （0.48, 0.85）. The further regional subgroup analysis showed that there was significant relevance between ABCB1 C3435T loci polymor-phism and antiepileptic drug resistant in India （P〈0.05）, but not in Chinese （P〉0.05）. In the allele gene model, OR=0.70, 95%CI （0.54, 0.93）;recessive gene model, OR=0.72, 95%CI （0.49, 1.07）. Conclusion ABCB1 C3435T loci polymor-phism dose not relate to the antiepileptic drug resistant among Chinese; but ABCB1 C3435T loci polymorphism relates to the antiepileptic drug resistant among Indian.

关 键 词：ABCB1 C3435T 基因多态性 META分析 耐药 

分 类 号：R742.1[医药卫生—神经病学与精神病学]