平衡针灸对肩周炎模型兔转化生长因子β1、前列腺素E-2、羟脯氨酸影响的实验研究  

Experimental research of balance acupuncture on rabbit's periarthritis of shoulder model for the influence of transforming growth factor beta 1,prostaglandin E-2 and hydroxyproline

作　　者：袁红[1] 陈榕[1] 黄大鹏[1] 武燕[1] 王颖[1] 王文远[1] 陈锋[1] 

机构地区：[1]北京中医药大学针灸推拿学院,100029

出　　处：《环球中医药》2015年第1期42-45,共4页Global Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2007CB512700)

摘　　要：目的探讨平衡针对家兔肩关节周围炎症治疗的作用及机制。方法家兔随机分为空白组、模型组和平衡针治疗组。采用持续机械劳损加冰敷造成肩周炎家兔模型,观察模型兔关节运动及患侧关节周围组织的病理变化并检测血浆和患侧局部组织中的转化生长因子-β1(transformating growth factor-β1,TGF-β1)和前列腺素-E2(prostaglandin E-2,PGE-2)及羟脯氨酸(hydroxyproline,HYP)的含量。结果采用单因素ANOVA,统计结果用LSD进行分析,得出平衡针组家兔肱二头肌中转化生长因子-β1(transformating growth factor-β1,TGF-β1)及冈上肌中前列腺素-E2(prostaglandin E-2,PGE-2)含量均较模型组明显降低,统计学差异极显著(P<0.01)。结论平衡针通过降低模型兔肩关节周围组织中转化生长因子-β1(transformating growth factor-β1,TGF-β1)、前列腺素-E2(prostaglandin E-2,PGE-2)及炎性组织中羟脯氨酸(hydroxyproline,HYP)的含量,实现消除水肿、镇痛、抗炎作用,值得在临床推广和应用。Objective Explore the effects and mechanism of rabbit scapulohumeral periarthritis （ SP ） model treated by balanced acupuncture .Methods Rabbits were divided into a blank group , a model group and a balanced acupuncture group .Establish the rabbit SP model by using persistent mechani-cal strain and ice compress .Observing the activities of rabbit sp model and the pathological change of ten -don of the tissue around the shoulder joint .Test the content of transforming growth factor-β1、prostaglandin E2 and hydroxyproline in plasma and local tissue .Results Use Single factor ANOVA to analyse the ex-perimental data,the results showed that compared with model group ,rabbit in the balanced acupuncture group presented both TGF-β1 in biceps and PGE-2 in supraspinatus muscle significantly lower , the differ-ence was statistically significant （P〈0.01）.Conclusion Balanced acupuncture by reducing the content of interleukin-1β, transforming growth factor-β1and prostaglandin E2 in the tissue around the shoulder joint of rabbit SP model and hydroxyproline in the inflammatory tissue to make the effects of eliminating edema , analgesia and anti-inflammatory.Balanced acupuncture by reducing the content of anti-pain factors and in-flammatory factors to improve the organization and adhesion of the local pathological tissue of rabbit SP model , then effectively treat the local and systemic syndromes .So it is valuable for widespread applying in clinic treatment .

关 键 词：平衡针 肩关节周围炎 转化生长因子-β1 前列腺素-E2 羟脯氨酸 

分 类 号：R245.3[医药卫生—针灸推拿学]