降钙素原对晚期泌尿系肿瘤患者中发热原因的评价研究  

The value of procalcitonin level in the determination of the cause of fever in patients with advanced urinary tract tumors

作　　者：杜琨[1] 黄光伟[2] 王超[2] 

机构地区：[1]首都医科大学附属北京友谊医院医务处,北京100050 [2]首都医科大学附属北京友谊医院感染内科,北京100050

出　　处：《临床和实验医学杂志》2015年第1期14-17,共4页Journal of Clinical and Experimental Medicine

基　　金：首都医学发展基金资助(项目编号2009-1034)

摘　　要：目的评价降钙素原(PCT)在鉴别晚期泌尿系肿瘤患者细菌感染性发热和非细菌感染性发热中的作用。方法收集77例体温高于38℃的晚期泌尿系肿瘤住院患者,按有无细菌感染分为细菌感染性发热组(n=32)和非细菌感染性发热组(n=45)。所有患者均在出现发热症状后立即行白细胞计数(WBC)、C反应蛋白(CRP)及PCT的检测并进行记录。结果细菌感染性发热及非细菌感染性发热两组的统计结果显示体温及WBC、CRP的差异不显著,P值均≥0.05;PCT在两组之间存在着明显的差异:细菌感染发热组较非细菌感染发热组显著增高(P=0.01)。相关性分析结果表明在细菌感染性发热组中,PCT水平不仅与体温的升高相关(r=0.647,P<0.001),而且与WBC密切相关(r=0.574,P=0.001)。结论 PCT水平的检测对于鉴别晚期泌尿系肿瘤的发热原因具有一定的价值,并且可以协助临床医生做出正确的临床决策。Objective To evaluate the roles of PCT in the differentiation of bacterial infectious fever and non - bacterial infectious fever in patients with advanced urinary tract tumors. Methods According to the presence or absence of bacterial infection,77 hospitalized urinary tract tumor patients with body temperature higher than 38℃ were divided into bacterial infectious fever group（n = 32）and non - bacterial infectious fe-ver groups（n = 45）. WBC,CRP,and PCT were detected immediately after the appearance of fever symptoms in all patients. The serological pa-rameters of the two groups were compared and analyzed. Results Significant differences in body temperature,WBC,and CRP were not found be-tween the two groups（all P ≥0. 05）. But in bacterial infectious fever group,PCT level increased significantly than in non - bacterial infectious fe-ver group（ P = 0. 01）. Correlation analysis revealed that in the bacterial infectious fever group PCT level was not only related to the rise of tem-perature（ r = 0. 647,P ﹤ 0. 001）but closely related to WBC count（ r = 0. 574,P = 0. 001）. Conclusion The detection of PCT level may contribute to the identification of the cause of fever in advanced urinary tract tumor patients and help clinician to make a correct clinical decision.

关 键 词：泌尿系肿瘤 发热 降钙素原 

分 类 号：R737.1[医药卫生—肿瘤]