慢性炎症与结直肠癌发生发展相关性的研究进展  

The latest progress in the development of the correlation between chronic inflammation and colorectal cancer

作　　者：朱红艳[1] 邢文婧[1] 任欢[1] 

机构地区：[1]哈尔滨医科大学免疫学教研室,150081

出　　处：《国际免疫学杂志》2015年第1期24-26,共3页International Journal of Immunology

基　　金：国家自然科学基金（91229112）

摘　　要：传统观点认为，炎症诱导的免疫反应能够抑制肿瘤的发生发展。进一步研究证实，慢性炎症也可能促进恶性肿瘤的发生和进展。其中，肿瘤炎症微环境中的细胞因子等炎性介质及其介导的信号转导通路在肿瘤发生发展中起着至关重要的作用。流行病学数据表明，应用非甾体类抗炎药（NSAIDs）可以延缓结直肠癌病情的进展。The traditional view is that the immune response induced by inflammation can inhibits the occurrence and development of tumor. Further studies confirm that chronic inflammation may also promote the occurrence and development of malignant tumor. Among of them, the cytokines and their mediated signal trans- duction pathways play a crucial role in tumor inflammatory microenvironment. Epidemiological data show that the application of non steroidal anti-inflammatory drug~ （non-steroidal anti-inflammatory drugs, NSAIDs） can delay the progression of colorectal disease. In this paper,we review the research progress on the correlation between inflammation and colorectal cancer.

关 键 词：炎症 结直肠癌 环氧合酶-2 前列腺素E2 核因子-ΚB 非甾体类抗炎药 

分 类 号：R735.34[医药卫生—肿瘤]