改善认知功能的植物多酚研究进展  

Research Progress of Plant Polyphenols for Improving Cognitive Function

作　　者：张伟[1] 胡永杰[1] 武海英[1] 李行舟[2] 

机构地区：[1]空军大连航空医学鉴定训练中心,大连116013 [2]军事医学科学院毒物药物研究所,北京100850

出　　处：《世界科学技术-中医药现代化》2014年第11期2454-2459,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81072529):针对肺部炎性疾病的p38MAPK抑制剂的设计;合成与筛选研究;负责人:李行舟

摘　　要：植物多酚是植物界中广泛存在的一类天然化学物质,是饮食中含量最丰富的抗氧化物质之一。流行病学及动物实验表明,植物多酚具有改善认知功能的作用。其作用机制已被广泛研究,包括抗氧化、抗炎、神经保护、改善脑血流等作用。鉴于植物多酚对认知功能的重要作用,目前已成为研究的热点,本文将对多酚类化合物的结构来源、对认知功能的作用及其作用机制等方面的研究进展进行综述。Plant polyphenols are a group of naturally occurring phytochemicals which are present in high amounts in plants and are the most abundant dietary antioxidants. Epidemiological and animal model researches have indicated that polyphenols can improve cognitive function. The mechanism for polyphenols to improve cognitive function has been extensively studied and may be owing to antioxidant, anti-imflammatory, neuroprotective, cerebrovascular blood flow increasing activities, and etc. Nowadays, the plant polyphenols and its benefits to cognitive function have become a hot research topic. In this article, we reviewed the latest progress from the structure and origin of phenolic compound, as well as its effect and action mechanism on cognitive function.

关 键 词：多酚 黄酮 认知功能 研究进展 

分 类 号：R284[医药卫生—中药学]