溶液黏度对相转化水凝胶微针制备的影响  

The Effect of Fabrication of Phase Transition Microneedles on Viscosity of Solutions Suitable

作　　者：洪晓芸[1] 陈丽竹[1] 吴造展[1] 张向荣 袁伟恩[1] 

机构地区：[1]上海交通大学药学院,上海200240 [2]深圳赛宝儿生物药业有限公司,广东深圳518129

出　　处：《现代生物医学进展》2014年第36期7007-7010,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81373366)

摘　　要：目的:选择黏度适宜的高分子溶液,制备相转化水凝胶微针。方法:通过考察两种型号的聚乙烯醇本身的黏度性质、溶液温度、几种不同性质的高分子材料,包括透明质酸、预胶化淀粉等可能影响聚乙烯醇溶液黏度的因素,使用粘度计测定其黏度值并作图比较,观察溶液黏度变化的规律。将所制溶液分别制备微针以观察针形的好坏,选择合适制备相转化水凝胶微针的溶液黏度范围。结果:实验表明黏度范围在2.5万至13万m Pa·s之间的聚合物溶液较为粘稠且流动性适宜。结论:在该黏度范围内的聚合物溶液可用以制备相转化水凝胶微针,适用于工业化生产。Objective ： The viscosity of polymer solutions to be casted into specific molds for the fabrication of phase-transition microneedles was investigated. Methods： The instinct viscosity properties of two types of polyvinyl alcohol（PVA） were investigated.The other factors including the temperature of solutions, the existence of different polymers, such as hyaluronic acid（HA）, and pregelatine starch（PCS）, were also studied. The viscosity values were measured with viscometer and curved to conclude the rule of viscosity change. The solutions were also used to fabricate microneedles to observe the appearance of needles to choose the suitable viscosity scope. Results： The experiences showed that the solution whose viscosity was within the scope of 25,000 to 130,000 m Pa·s was with proper mobility. Conclusions： The solutions with the above mentioned viscosity was suitable for the manufacturing of good shape microneedles in commercial processes.

关 键 词：黏度 相转化水凝胶微针 聚乙烯醇 

分 类 号：R944.2[医药卫生—药剂学] R945[医药卫生—药学]