Pokemon在小细胞肺癌中的表达及临床意义  

Expression and Clinical Significances of Pokemon in Small Cell Lung Cancer

作　　者：赵智宏[1] 王胜发[1] 姜久仰[1] 高大登[1] 王巨[1] 常浩[1] 曲俊峰[1] 

机构地区：[1]哈尔滨医科大学附属第一医院胸外科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2014年第36期7147-7150,7063,共5页Progress in Modern Biomedicine

基　　金：黑龙江省卫生厅基金项目(2011-026)

摘　　要：目的:检测Pokemon在小细胞肺癌(SCLC)中的表达情况,并探讨其在SCLC发生、发展中的作用及临床意义。方法:应用SP免疫组化方法检测Pokemon在52例SCLC肿瘤组织及20例病灶旁正常组织中的表达。结果:Pokemon在正常肺组织中不表达,52例SCLC组织中,35例呈阳性表达,占67.3%。Pokemon的表达与SCLC患者的性别、年龄、吸烟、淋巴结转移情况均无关(P>0.05),而与TNM分期显著相关(P<0.05)。Pokemon阳性表达者生存期明显短于阴性表达者,二者比较差异有统计学意义(P<0.05)。单因素分析结果显示TNM分期、Pokemon的表达与SCLC患者的预后相关;多因素分析结果显示仅Pokemon的表达与SCLC患者的预后显著相关(P=0.013)。结论:Pokemon在SCLC组织中呈高表达,预示SCLC患者的预后较差,Pokemon表达可能作为SCLC的独立预后预测因素。Objective： To study the expression and clinical significances of Pokemon gene in the small cell lung cancer（SCLC）.Methods： Immunohistochemistry was applied to detect the expression of Pokemon protein in 52 cases of SCLC and 20 cases of tumor-surrounding normal lung tissues. Results： Pokemon didn＇t express in normal lung tissues and expressed in 35 cases（67.3%） of 52 cases of SCLC. The expression of Pokemon gene had no correlation with the sex, age, smoking, or lymph node metastasis of the patients with SCLC（P〉0.05）, but it was obviously related to the TNM stages（P〈 0.05）. The survival time of patients with positive expression of Pokemon was significantly shorter than those with negative expression of Pokemon（P〈 0.05）. Univariate analysis showed that TNM stage and Pokemon expression were correlated with the prognosis of SCLC patients, while multivariate analysis showed the expression of Pokemon was the single factor related to the prognosis of SCLC patients.（P=0.013）. Conclusions： High expression of Pokemon gene was found in SCLC, which indicated the poor prognosis of SCLC patients. The expression of Pokemon may be used as an independent prognostic factor of SCLC.

关 键 词：小细胞肺癌 POKEMON 表达 预后 

分 类 号：R734.2[医药卫生—肿瘤]