利用系统进化树对H7N9大数据预测传播模型的评估  

Evaluation of the H7N9 Transmission Model Predicted by Big Data by Phylogenetic Tree

作　　者：杜鹏程[1,2] 于伟文[1,2] 陈禹保[3] 闫鹏程[3] 安云鹤[4] 陈晨[1,2] 

机构地区：[1]中国疾病预防控制中心传染病预防控制所传染病预防控制国家重点实验室,北京102206 [2]感染性疾病诊治协同创新中心,杭州310003 [3]北京市计算中心,北京100094 [4]北京市理化分析测试中心,北京100089

出　　处：《中国生物工程杂志》2014年第11期18-23,共6页China Biotechnology

基　　金：国家"863"计划(2014AA021505);国家自然科学基金(81201322;81301402)资助项目

摘　　要：活禽贸易和H7N9禽流感病毒传播之间存在关联,应用大数据技术分析活禽交易网络数据,可进行疫情溯源并预测未来传播趋势。从流感研究数据库中获取了截止至2013年分离得到的H7N9毒株的血凝素基因核酸序列,构建系统进化树推断2013年上半年疫情中H7N9在各省及城市间的传播情况,并与大数据推断结果进行对比分析。结果表明,系统进化树推断结果更为准确,但大数据分析能够提供更多地区的信息且具有更好的时效性,同时推断的传播模型准确度较高,在H7N9疫情的应对中具有较高的应用价值。It has been widely proved that the emergence and transmission of H7N9 avian influenza in China 2013 is closely associated with the live poultry trading all over the China's Mainland. By analyzing the poultry trading information in China's Mainland from websites using big data analysis technology, we could perform the work of H7N9 outbreak tracing,transmission analysis and trend prediction. In current study, we obtained the nucleotide sequences of hemagglutinin gene of H7N9 avian influenza virus isolates collected before 2013 from the Influenza Research Database firstly, and then conducted phylogenetic analysis using maximum likelihood method by RAxML software. A phylogenetic tree was constructed and then based on the phylogenetic relationship and isolate background including sources, time and locations of collection, we built several transmission routes of H7N9 between provinces and cities during the outbreak emerged in China in the first half of 2013. The results from phylogenetic analysis were compared with the ones from big data analysis to modify the transmission model which has been built by the big data method in our previous research. It revealed that the phylogenetictree could provide more accurate transmission information to trace the real route which could be used to complete and modify the model from big data, but the connection and transmission model from big data analysis could provide nearly accurate information from larger areas in time, which is meaningful in facing the H7N9 outbreak and could provide valuable basis for setting up and carrying out health policy and measures of disease control and prevention.

关 键 词：H7N9型禽流感 系统进化树 大数据 传播模型 

分 类 号：R181[医药卫生—流行病学]