色素性微囊肾嫌色细胞癌临床病理观察  

Pigmented microcystic chromophobe renal cell carcinoma: a clinicopathological analysis

作　　者：秦桂萍[1] 侯海娜[1] 华玉兰[1] 齐淋喆[1] 

机构地区：[1]首都医科大学良乡教学医院病理科,北京102401

出　　处：《诊断病理学杂志》2014年第12期744-746,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨色素性微囊肾嫌色细胞癌的临床病理特点、诊断及鉴别诊断。方法对1例色素性微囊肾嫌色细胞癌的临床资料、组织学形态及免疫组化结果进行分析,并复习相关文献。结果肿瘤界限清楚,无明显包膜;切面灰白、灰黄至棕黄色。镜下瘤细胞排列呈微囊及腺样结构,可见色素沉着,肿瘤间质内可见钙化灶。免疫组化:瘤细胞CAM2.5、AE1/AE3、CK7、EMA、E-cadherin和CD117(+),S-100、HMB45和vimentin(-)。结论色素性微囊肾嫌色细胞癌是一种少见的肿瘤,最重要的特征是具有相对良性的生物学行为,远处转移很少见。Objective To investigate the clinicopathologic features, diagnosis and differential diagnosis of pigmented microcystic chromophobe renal cell carcinoma. Methods One case of pigmented microcystic chromophobe renal cell carcinoma was studied by clinical data analysis, histomorphology and immunohistochemistry with review of the related literatures. Results Grossly, the tumor was well-demarcated, but no capsule. On section, the tumor was light gray to brown yellow. Histologically, the tumor showed a microcystic arrangement and formation of adenomatous structures. There was brown pigmentation located in the cytoplasm of the tumor cells and extracellularly. Focally, microscopical calcifications were found. Immunohistochemieally, the tumor cells were positive for CAM2 . 5, AE1/AE3, CK7, EMA, E-cadhcrin and CDl17, but negative for S-100, HMB45 and vimentin. Conclusions Pigmented microcystic chromophobe renal cell carcinoma seems to have a relatively benign biological behavior, but distant metastases are absent.

关 键 词：色素性微囊肾嫌色细胞癌 病理诊断 免疫组化 

分 类 号：R737.11[医药卫生—肿瘤]