神经生长因子及其受体p75在乳腺癌中的表达  

The expression of nerve growth factor and its receptor p75 in breast cancer

作　　者：章菊[1] 叶书来[1] 张昌龙[1] 周倩[1] 

机构地区：[1]安徽省医科大学附属安徽省立医院检验科,安徽合肥230071

出　　处：《蚌埠医学院学报》2014年第12期1604-1606,共3页Journal of Bengbu Medical College

基　　金：安徽省教育厅自然科学研究基金资助项目(KJ2012Z176)

摘　　要：目的:探讨神经生长因子(NGF)及其低亲和力受体p75在乳腺癌中的表达及其意义。方法:采用PV-9000免疫组织化学方法检测118例乳腺疾病患者病灶组织中NGF和p75的表达。结果:NGF在乳腺癌上皮细胞中表达,在恶性肿瘤中阳性率高于良性肿瘤(P<0.01),在原位癌和浸润癌中阳性率差异无统计学意义(P>0.05);p75在乳腺的肌上皮细胞表达,在良性肿瘤中的阳性率高于恶性肿瘤(P<0.01)。NGF阳性率在肿瘤的分级、年龄、淋巴结转移间差异均无统计学意义(P>0.05),p75阳性率在年龄间差异无统计学意义(P>0.05),而在肿瘤的分级和淋巴结转移间表达阳性率差异均有统计学意义(P<0.01和P<0.05)。结论:NGF可能是乳腺癌发生、发展的分子事件,但与乳腺癌的浸润性进展无关;p75可作为乳腺癌恶性程度的分子标志物。Objective：To explore the expression and significance of nerve growth factor （ NGF ） and its receptor （ p75 ） in breast cancer. Methods：The expressions of NGF and p75 in cancer tissuo of 118 patients with breast disease were detected using immunohistochemical method of PV-9000. Results：The NGF expression in mammary tumor epithelial cells was detected,the positive expression rate of NGF in malignant tumor was higher than that in benign tumor（P〈0. 05）,the difference of the NGF expression in situ and invasive carcinoma was not statistically significant（P〉0. 05）. The p75 expression in the mammary gland myo-epithelial cells was detected,the positive expression rate of p75 in benign tumor was higher than that in malignant tumor（P〈0. 05）. The differences of the positive expression rate of NGF in tumor grade and lymph node metastasis,and patient age were not statistically significant（P〉0. 05）. The difference of the positive expression rate of p75 in patient age was not statistically significant（P〉0. 05）,but in tumor grade and lymph node metastasis,the differences were statistically significant（P〈0. 01 and P〈0. 05）. Conclusions：NGF may be a molecular event of the occurrence and development of breast cancer,but it is unrelated with the invasion of breast cancer. p75 can be used as a molecular marker of malignant degree of breast cancer.

关 键 词：乳腺肿瘤 神经生长因子 P75 

分 类 号：R737.9[医药卫生—肿瘤]