创伤后应激障碍对慢性不可预见性应激抑郁模型的影响  

Effects of Posttraumatic Stress Disorder on Chronic Unpredictable Stress Depression Model

作　　者：金利[1] 田蜜[1] 刘晓宇[1] 吴智方[1] 刘芳芳[1] 

机构地区：[1]南京军区南京总医院麻醉科,江苏南京210002

出　　处：《现代生物医学进展》2015年第3期422-424,452,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年科学基金项目(81300946)

摘　　要：目的:观察创伤后应激障碍(PTSD)对慢性不可预见性应激(CUS)抑郁模型的影响。方法:采用足底电击的方法建立大鼠创伤后应激障碍模型。成年雄性S-D大鼠40只随机分为四组(n=10):对照组(C组)、PTSD组、CUS组、PTSD+CUS组(P+C组)。在1、7、14、21天测量大鼠体重,并行糖水偏好和强迫游泳实验,在7、14、21天做条件性恐惧实验。结果:与C组相比,CUS组和P+C组体重增加缓慢,PTSD组体重正常。CUS组于第21天出现糖水消耗比例降低,强迫游泳不动时间增加。P+C组于第14天即出现上述抑郁表现。条件性恐惧实验中,PTSD组与PTSD+CUS组僵直时间显著增加,CUS组无明显变化。结论:创伤后应激障碍的动物更易产生抑郁表现。Objective： To investigate the effects of posttraumatic stress disorder （PTSD） on chronic unpredictable stress （CUS） depression model. Methods： Footshocks were applied to establish PTSD model. Forty adult male Sprague-Dawley rats were randomly divided into the following four groups （n= 10）：control group （C group）, PTSD group, CUS group, and PTSD＋CUS group （P＋C group）. The rats were weighted and subjected to sucrose preference test and forced swim test, and fear conditioning test on the 1st day, 7th day, the 14th day and the 21st day. Result： Compared with that of C group, the weight of CUS group and P＋C group increased slowly. Depression occurred on the 21st day in CUS group, whereas on the 14th day in the group P＋C. Depressive symptom including sucrose consumption ratio decreased significantly while immobility time increased. The freezing time of PTSD group and P＋C group significantly increased in the fear conditioning test. Conelusiun： Animals with post-traumatic stress disorder are more susceptible to depression.

关 键 词：创伤后应激障碍 慢性不可预见性应激抑郁模型 糖水偏好 强迫游泳 

分 类 号：R-332[医药卫生] R651