Netrin-1在炎症相关疾病中的作用  

Role of Netrin-1 in Inflammation-based Diseases

作　　者：沈丕杰[1] 颜荣林[1] 王长明[1] 杨德君[1] 卫子然[1] 陈吉[1] 

机构地区：[1]第二军医大学上海长征医院普外科,上海200003

出　　处：《现代生物医学进展》2015年第3期551-553,568,共4页Progress in Modern Biomedicine

摘　　要：近年研究发现神经突起导向因子Netrin-1能够抑制白细胞向炎症部位迁移和募集从而避免局部组织炎症反应过度。因此,Netrin-1可能成为未来抗炎治疗新靶点,具有良好的临床应用前景。Netrin-1的抗炎作用在急性腹膜炎、组织再灌注损伤、急性肺损伤,炎症性肠病,角膜炎,急性胰腺炎等动物模型中已有初步的研究结果,一些结果提示Netrin-1的抗炎作用主要通过结合腺苷A2b受体、UNC5B受体实现。对于不同的疾病情况,Netrin-1可同时通过MAPKs、ERKs、p38、NF-k B等多条信号转导途径协同双向调控白细胞的迁移及募集过程,达到减轻组织氧化应激反应,减轻组织器官的过度炎症反应的作用,在各炎症反应模型中证明Netrin-1对重要组织器官起到保护的作用。本文对Netrin-1在多种炎症相关疾病模型中的不同作用及其机制进行分析和总结,并重点讨论相关研究的最新进展。Recent work has showed that the neuronal guidance protein netrin-1 is a negative guidance cue for leukocyte migration and can avoid excessive inflammation. Moreover, recent data suggest that netrin-1 can be promising targets for anti-inflammation therapies. The anti-inflammatory effects of Netrin-1 have been comfirmed in several animal models such as acute peritonitis, tissue reperfusion injury, acute lung injury, inflammatory bowel disease and so on. Some results indicated that the anti-inflammatory effects of Netrin-1 achieved through adenosine A2b receptor and UNC5B receptor. For different diseases, Netrin-1 can regulate inflammation reaction through MAPKs, ERKs, p38, NF-kB and other signal transduction pathways. This regulation can lighten tissue oxidative stress and inflammatory response to avoid the tissue injury. Several animal model researches show that Netrin-1 can protect the organ in some inflammatory diseases. This review aims to briefly summarize and discuss the recent experimental findings regarding the role of netrin- 1 in various inflammation-based diseases.

关 键 词：NETRIN-1 炎症 白细胞迁移 

分 类 号：R364.5[医药卫生—病理学]