肿瘤转移抑制基因-1与肿瘤关系的研究进展  

Tumor metastasis suppressor gene-1 and tumors

作　　者：杨波[1] 何晓彬[1] 

机构地区：[1]泸州医学院附属医院消化内科,四川省泸州市646000

出　　处：《世界华人消化杂志》2014年第34期5291-5297,共7页World Chinese Journal of Digestology

摘　　要：肿瘤转移抑制基因-1(tumor metastasis suppressor gene-1,TMSG-1)是一个新发现的肿瘤转移抑制基因,在促进肿瘤细胞凋亡和抑制肿瘤细胞浸润和转移中起着重要的作用.TMSG-1抑制肿瘤的机制,主要可能与V-ATPase和神经酰胺有关.本文就TMSG-1的发现、编码蛋白的结构、抑制肿瘤浸润和转移的可能机制、在各类肿瘤中的表达和意义以及应用前景等作一综述.Tumor metastasis suppressor gene-1（TMSG-1） is a newly discovered tumor metastasis suppressor gene that plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells. The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H＋-ATPase and ceramide, but the underlying mechanism remains unknown. This review discusses the discovery of TMSG-1, the structure of TMSG-1 protein, as well as its possible mechanisms of action, expression in tumors and applications.

关 键 词：肿瘤转移抑制基因-1 人源性长寿保障基因2 空泡型-ATP酶 神经酰胺 

分 类 号：R730.2[医药卫生—肿瘤]