直肠黏液腺癌p53、nm23基因的表达及临床病理意义  

Significance of expression of p53 and nm23 in mucous adenocarcinoma of the rectum

作　　者：杨成万[1] 陶明珠[2] 

机构地区：[1]泸州医学院附属医院病理科,四川省泸州市646000 [2]泸州医学院附属医院肿瘤科,四川省泸州市646000

出　　处：《世界华人消化杂志》2014年第34期5385-5388,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨直肠黏液腺癌(mucous adenocarcinoma,MUC)中p53及nm23的表达及临床意义.方法:应用免疫组织化学SP法检测37例直肠MUC及261例直肠非黏液腺癌(non-mucous adenocarcinoma,non-MUC)组织中p53及nm23蛋白的表达水平,并分析其与临床病理指标的关系.结果:MUC组p53、nm23高表达阳性率(16.2%、13.5%)分别明显低于non-MUC组(35.6%、29.9%).MUC组p53及nm23表达,与患者年龄、性别、肿瘤大小、浸润深度、淋巴结转移和临床分期均无相关性,nm23表达与p53表达无相关性.结论:p53和nm23在直肠MUC中的表达低,并且在直肠MUC的发生、发展中无明显作用.AIM： To investigate the clinical significance of expression of p53 and nm23 in mucous adenocarcinoma（MUC） of the rectum. METHODS： The expression of p53 and nm23 in 37 cases of MUC and 261 cases of non-MUC of the rectum was detected by using immunohistochemical streptavidin-peroxidase method. RESULTS： The positive rates of high p53 and nm23 expression in MUC were significantly lower than those in non-MUC（16.2% vs 35.6%, 13.5% vs 29.9%, P 〈 0.05 for both）. The expression of p53 and nm23 was not correlated with tumor size, gender, invasion depth, 1ymph node metastasis or TNM stage（P 〉 0.05 for all）. Nm23 expression was not related to p53 expression. CONCLUSION： The expression of p53 and nm23 is low in rectal MUC, and they may have no significant role in the development and progression of this malignancy.

关 键 词：直肠 黏液腺癌 P53 NM23 

分 类 号：R735.3[医药卫生—肿瘤]