中国人群GSTT1基因多态性与胃癌易感性关系的Meta分析  

Association between GSTT1 gene polymorphism and gastric cancer susceptibility in Chinese population: A Meta-analysis

作　　者：刘宁[1] 张成武[1] 王晓龙[1] 

机构地区：[1]青海大学附属医院胃肠外科,青海西宁810000

出　　处：《中国普通外科杂志》2014年第12期1658-1663,共6页China Journal of General Surgery

摘　　要：目的：系统评价中国人群谷胱甘肽转移酶T1（GSTT1）基因多态性与胃癌易感性的关系。方法：检索多个国内外数据库,收集有关中国人群CSTT1基因多态性与胃癌易感性的病例对照研究,以病例组和对照组GSTT1基因型分布行Meta分析。结果：最终纳入17篇病例对照研究,其中病例组胃癌患共者2 468例,对照组健康人群共4 745例。Meta分析结果显示,CSTT1基因缺失型者胃癌的危险性较CSTT1基因存在型者明显增高,固定效应模型和随机效应模型的合并OR值分别为0.84（95%CI=0.76~0.93）与0.83（95%CI=0.71~0.96）。按样本量进行亚组分析结果显示,样本量〉100的研究合并OR值为0.87（95%CI=0.77~0.98）,样本量≤100的研究合并OR值为0.77（95%CI=0.63~0.94）。结论：中国人群GSTT1基因多态性与胃癌易感性密切相关,GSTT1基因缺失型者与胃癌的发生的风险增加。Objective： To systematically assess the association between the gene polymorphism of glutathione S-transferases T1（GSTT1） and gastric cancer susceptibility in Chinese population.Methods： The case-control studies on relationship between GSTT1 gene polymorphism and gastric cancer susceptibility in Chinese population were collected by searching several national and international databases. Meta-analysis was performed according to the GSTT1 genotype distributions in case group and control group.Results： Seventeen case-control studies were finally selected, with a total of 2 468 gastric cancer patients in case group and a total of 4 745 healthy subjects in control group. Results of the Meta-analysis indicated that the risk of gastric cancer was increased in subjects with GSTT1 null genotype compared with those with GSTT1 presentgenotype, and the pooled OR in i xed-effect model and random-effects model was 0.84（95% CI=0.76–0.93） and 0.83（95% CI=0.71–0.96）, respectively. Results of subgroup analysis according to sample size showed that the pooled OR was 0.87（95% CI=0.77–0.98） for studies with sample size larger than 100 and was 0.77（95% CI=0.63–0.94） for studies with sample sized equal to or less than 100, respectively.Conclusion： GSTT1 gene polymorphism is closely associated with gastric cancer susceptibility in Chinese population, and those with GSTT1 null genotype face an increased risk of gastric cancer.

关 键 词：胃肿瘤 谷胱甘肽转移酶 多态现象 遗传 META分析 

分 类 号：R735.2[医药卫生—肿瘤]