双相障碍Ⅰ型患者微小躯体异常的研究  

The study on the minor physical anomalies in patients with bipolar I disorder

作　　者：李烜[1] 李卓丽[1] 梁卉薇[1] 邓文皓[1] 张晓菲[1] 罗添云[1] 饶冬萍[1] 曹莉萍[1] 林鄞[1] 

机构地区：[1]广州市惠爱医院(广州市精神病医院,广州市脑科医院),广州510370

出　　处：《中国神经精神疾病杂志》2014年第11期673-676,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：广东省科技计划项目(编号:);广州市医药卫生科技项目(编号:20131A011089)

摘　　要：目的：调查双相障碍Ⅰ型患者微小躯体异常（minor physical anomalies，MPAs），了解双相障碍患者是否存在神经发育异常。方法收集16-45岁双相障碍I型患者118例，健康人群101名作为对照组，采用躯体异常量表的部分条目及新增条目进行MPAs评定。结果患者组头顶漩涡对称者较对照组多（52.1%vs.31.4%）而偏右者少（30.9%vs.50.0%）；内眦赘皮者较对照组增多（23.7%vs.11.9%）；外眼距较对照组增宽[（10.13±0.59） mm vs.（9.88±0.57）mm]，差异均有统计学意义（均P＜0.05）。两组间头围、内眼距、耳际过低、耳末粘附、外耳廓曲线不规则、舌裂纹、通关掌、长的大拇指、右手第二指长度与右手第四手指长度之比（2D：4D）的差异均无统计学意义（P＜0.05）。结论双相障碍Ⅰ型患者可能存在神经发育异常。Objective To investigate the minor physical anomalies and to examine the neurodevelopmental de？fects in patients with bipolar I disorder. Methods Several original items and newly added items from the Waldrop Scale were used to investigate the minor physical anomalies in 118 patients with bipolar I disorder and 101 healthy controls aged from 16 to 45. Results Compared with healthy controls, patients had significantly greater outer canthus distance [（10.13±0.59） mm vs. （9.88 ± 0.57） mm] and more epicanthus （23.7% vs. 11.9%）（P〈0.05）. Whorls on head were more symmetry in patients than that in healthy controls （52.1%vs. 31.4%）（P〈0.05）. Conclusions Patients with bipolar I disor？der may have abnormal neurodevelopment.

关 键 词：双相障碍 微小躯体异常 神经发育 

分 类 号：R749.4[医药卫生—神经病学与精神病学]