弥漫大B细胞淋巴瘤治疗后继发急性早幼粒细胞白血病1例并文献复习  

A case report of secondary acute promyelocytic leukemia after treatment of diffuse large B-cell lymphoma and literature review

作　　者：胡蓓莉[1] 王宙政[1] 王兆丰[1] 韩艳霞[1] 黄菊[1] 陈丽花[1] 

机构地区：[1]嘉兴市第二医院血液科,浙江嘉兴314000

出　　处：《临床血液学杂志》2015年第1期72-74,共3页Journal of Clinical Hematology

摘　　要：随着现代诊疗技术的提高,大剂量化疗和靶向药物的应用,淋巴瘤的生存期延长;同时反复化疗后继发的治疗相关性急性髓系白血病（AML）/骨髓增生异常综合征（MDS）发生率也不断上升,并成为非霍奇金淋巴瘤（NHL）预后不良的远期并发症之一。A diffuse large B-cell lymphoma patient after 7cycles treatment of CHOP combined with thrombocytopenia,coagulation abnormalities was diagnosed APL after bone marrow cytology,pathology,chromosome,gene fusion.The previous treatment and chemotherapy constituted of tretinoin,daunorubicin,cytarabine and arsenic trioxide induced differentiation invalided,the patient deteriorated rapidly and died.

关 键 词：非霍奇金淋巴瘤 白血病 早幼粒细胞 急性 继发 

分 类 号：R733.4[医药卫生—肿瘤]