腹膜透析患者血清成纤维细胞生长因子23的变化及意义  

Fibroblast growth factor 23 in patients undergoing peritoneal dialysis

作　　者：刘思[1] 刘佳[1] 毛慧娟[1] 

机构地区：[1]南京医科大学第一附属医院肾内科,南京210029

出　　处：《肾脏病与透析肾移植杂志》2014年第6期568-572,共5页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金："十二五"国家科技支撑计划项目(2011BAI10B08);江苏省卫生厅医学科研基金项目(Z201002)

摘　　要：成纤维细胞生长因子23(FGF23)是一种调节磷及矿物质代谢的蛋白质,主要生理功能是增加肾脏的磷排泄。众多研究发现,慢性肾脏病(CKD)患者血清FGF23水平的升高早于血磷、甲状旁腺素等指标的升高,对多种CKD及透析并发症具有预测意义。现就FGF23的来源及体内代谢过程,其在CKD尤其在腹膜透析患者血清中的改变和影响因素等方面做如下综述。Fibroblast growth factor 23 （ FGF23 ） is a novel factor and plays an important role in phosphorus metabolism. Many studies have reported that the serum FGF23 increased earlier than serum phosphorus or parathyroid hormone （PTH） in patients with chronic kidney diseases （CKD）, and that FGF23 may be a predictor of complications in patients with CKD and dialysis. This review will focus on the researches about FGF23 in patients with CKD, especially in patients undergoing peritoneal dialysis.

关 键 词：腹膜透析 成纤维细胞生长因子23 慢性肾脏病 FIBROBLAST growth FACTOR 23 

分 类 号：R459.5[医药卫生—治疗学]