MiR-146a rs2910164基因多态性与胃癌易感性的系统评价  

Systematic Review of the Association between MiR- 146a rs2910164 Gene Polymorphism and Susceptibility to Gastric Cancer

作　　者：谢文群[1] 谭诗云[1] 王晓凡[1] 

机构地区：[1]武汉大学人民医院消化内科,430060

出　　处：《医学研究杂志》2014年第12期81-85,共5页Journal of Medical Research

摘　　要：目的 评价miR-146a rs2910164 G/C基因多态性与胃癌易感性的相关性.方法 全面检索Pubmed、Excerpta Medica Database （Embase）、Chinese Biomedical Literature Database （CBM） and the Cochrane Library、维普、万方数据库,收集研究miR-146a rs2910164 G/C基因多态性与胃癌易感性相关性的文献.对miR-146a rs2910164 G/C各基因型的比较模型（G vs C、GG vs CC、GG vs GC、GC vs CC、GG＋GC vs CC、GGvs GC＋CC）进行定量综合分析.结果 共纳入8篇文献,共有胃癌患者4198例,健康对照5853例.Meta分析结果发现MiR-146a rs2910164 G/C基因多态性与胃癌易感性之间具有相关性（GG vsGC：OR=1.14,95％ CI：1.03～1.27,P=0.01;GG vs GC＋ CC：OR=1.17,95％ CI：1.06 ～ 1.29,P=0.002）.在亚组分析中也有相似的结论.结论 本研究发现miR-146a rs2910164基因多态性与胃癌易感性之间具有相关性,并且miR-146a rs2910164的等位基因G可能是胃癌的危险因素.Objective To systematically evaluate the association between miR-146a rs2910164 polymorphism and susceptibility to gastric cancer by meta-analysis.Methods A comprehensive electronic search for articles was conducted in PubMed,Excerpta Medica Database （Embase）,Chinese Biomedical Literature Database （CBM）,the Cochrane Library,Weipu and Wanfang database.We collected all the publications about the association between miR-146a rs2910164 polymorphism and risk of gastric cancer.Then,we analyzed the difference of miR-146a rs2910164 genotype（G vs C、GG vs CC、GG vs GC、GC vs CC、GG ＋ GC vs CC、GG vs GC ＋ CC）between cases and controls through meta-analysis.Results Ultimately,a total of 8 studies （4198 cases and 5853 controls） were found to be eligible for meta-analysis.The results of our meta-analysis suggested that miR-146a rs2910164 polymorphism was more likely to be associated with gastric cancer risk.In the overall analysis,significantly increased cancer risks were found in two comparisons （GG vs GC：OR =1.14,95％CI：1.03-1.27,P =0.01; GGvsGC＋CC：OR =1.17,95％CI：1.06-1.29,P=0.002）.Similarresults can be found among some subgroups when stratified analysis by subgroup.Conclusion This meta-analysis suggested that miR-146a rs2910164 polymorphism was more likely to be associated with gastric cancer risk.Besides,the G allel of rs2910164 might be a risk factor for gastric cancer.

关 键 词：MIR-146A 基因多态性 胃癌 META分析 

分 类 号：R73[医药卫生—肿瘤]