经尿道电切术联合吡柔比星灌注治疗浅表性膀胱肿瘤的临床研究  

Clinical research of transurethral resection combined with pirarubicin infusion in the treatment of superficial bladder tumor

作　　者：胡文豪 周小波[2] 

机构地区：[1]宁波市鄞州人民医院泌尿外科,浙江宁波315000 [2]浙江大学医学院附属邵逸夫医院泌尿外科,浙江杭州310016

出　　处：《中国现代医生》2015年第3期32-34,共3页China Modern Doctor

基　　金：浙江省医药卫生一般研究计划(2011KYA091)

摘　　要：目的：探讨经尿道电切术联合吡柔比星灌注治疗浅表性膀胱肿瘤的的疗效。方法2010年6月～2012年6月我院在行经尿道电切术治疗后联合吡柔比星灌注治疗浅表性膀胱肿瘤32例，设为观察组，另选择同期行经尿道电切术治疗后联合丝裂霉素灌注治疗浅表性膀胱肿瘤30例，设为对照组，比较①两组手术时间、术后留置导尿管时间、住院时间；②两组患者治疗后的并发症及复发情况。结果两组患者均一次手术成功，TURBT术时间为10～65 min；两组术中出血量均较少，观察组仅2例、对照组仅3例术后出血较明显，再次置入电切镜均成功止血；观察组患者的手术时间、术后留置导尿管时间、住院时间与对照组比较，差异无统计学意义（P＞0.05）；治疗后，两组患者均未发现明显的肝肾功能损害及全身反应，其中观察组出现尿频、尿痛及血尿的例数显著少于对照组（P＆lt;0.05），且随访2年，主要检查项目为B超、CT、膀胱镜检，两组均无一例死亡，其观察组复发率也显著低于对照组，差异有统计学意义（P＆lt;0.05）。两组术后6个月内未有复发病例出现，观察组及对照组均在术后9～12个月出现1例、5例复发患者，均为非原位复发。结论经尿道电切术联合吡柔比星灌注治疗浅表性膀胱肿瘤疗效确切，复发率低，值得推广和应用。Objective To explore the curative effect of transurethral resection combined with pirarubicin infusion in the treatment of superficial bladder tumor. Methods From June 2010 to June 2012 in our hospital undergoing transurethral resection after treatment combined with pirarubicin instillation for the treatment of superficial bladder tumor in 32 cases , set up in the observation group, the otherunderwent transurethral resection after treatment with mitomycin irrigation in treatment of superficial bladder tumor in 30 cases, set up as the control group,1） comparison of the observation group group and control group, operation time,postoperative indwelling catheter time, hospitalization time; 2） complications and recurrence of the two groups after treatment. Results The two groups of patientswere a successful operation , TURBT operation time was 10-65 min. Two groups of intraoperative bleeding was less , the observation group 2 cases , control grouponly only 3 cases of postoperative bleeding obvious , reimplanted resectoscope were successful hemostasis. The operation time,postoperative indwelling catheter time, hospitalization time in the observation group compared with the control group, there was no significant difference （P＆gt;0.05）. After treatment, liver and kidney function damage obvious and systemic reaction was not found in the two groups of patients , the number of cases of occurrence frequent micturition, dysuria and hematuria of the observation group was significantly less than that of the control group （P＆lt;0.05）, and followed up 2 years, the main inspection items for B ultrasound, CT, cystoscopy, and no case of death in both two groups, the observation group was significantly lower than that of control group, the recurrence rate of recur-rent rate, with significant difference （P＆lt;0.05）. The emergence of 6 months without recurrence after operation in the two groups, the observation group 1 case, control group 5 cases of recurrent patients were appeared in 9-12 months after operation,

关 键 词：浅表性膀胱肿瘤 经尿道电切术 吡柔比星 灌注治疗 复发率 

分 类 号：R737.14[医药卫生—肿瘤]