白细胞介素16基因多态性与卵巢癌的相关性  

Association between IL-16 polymorphisms and risk of ovarian cancer

作　　者：黄娟 李丹青[2] 孟健[2] 何跃东[2] 

机构地区：[1]四川省成都市妇女儿童中心医院妇产科,四川成都610091 [2]四川大学华西第二医院妇产科,四川成都610041

出　　处：《中国优生与遗传杂志》2015年第1期14-15,63,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨白细胞介素16基因(IL-16)rs4778889、rs11556218和rs4072111多态性与卵巢癌易感性的关系。方法收集285例健康对照和198例卵巢癌患者外周静脉血,采用聚合酶链反应-限制性片段长度多态性方法分析IL-16基因多态性与卵巢癌的相关性。结果 rs11556218TG基因型在卵巢癌中的频率为50.5%,明显高于其在对照组中的频率38.9%(χ2=6.65,校正OR=1.70,95%CI:1.16-2.48,P=0.006);rs11556218TG/GG基因型在卵巢癌中的频率为54.5%,明显高于其在对照组中的频率42.8%(χ2=6.45,校正OR=1.66,95%CI:1.15-2.40,P=0.007)。rs4778889和rs4072111基因型频率在卵巢癌和对照组中的分布差异无统计学意义(P>0.05)。结论 IL-16基因rs11556218多态性与卵巢癌的易感性有关。Objective： To investigate the association between IL-16 polymorphisms （i.e. rs4778889, rs11556218, and rs4072111 ） and risk of ovarian cancer. Methods： 285 healthy controls and 198 patients with ovarian cancer were collected. The relationship between the IL-16 polymorphisms and the risk of ovarian cancer was analyzed using polymerase chain reaction- restriction fragment length polymorphism assay. Results： The frequency of the IL-16 rs11556218TG genotype in patients with ovarian cancer was significantly higher than that in healthy controls （50.5% vs. 38.9%, Х^2=6.65, adjusted OR=1.70, 95%CI： 1.16-2.48, P=0.006） . The frequency of the IL-16 rs 11556218TG/GG genotypes in patients with ovarian cancer was significantly higher than that in healthy controls （54.5% vs. 42.8%, Х^2=6.45, adjusted OR=1.66, 95%CI： 1.15-2.40, P=0.007） . No significant association was observed between the IL-16 rs4778889 and rs4072111 polymorphisms and risk of ovarian cancer （P〉0.05） . Conclusion： IL-16 rs i 1556218 polymorphism may be associated with the susceptibility to ovarian cancer.

关 键 词：白细胞介素16 多态性 卵巢癌 聚合酶链反应-限制性片段长度多态性 

分 类 号：R737.31[医药卫生—肿瘤]