55例早期自然流产绒毛染色体检查及其结果分析  

The Analysis of chromosome karyotypes of 55 abortion villus and it′s relevant factors

作　　者：梁营秋 高天旸[1] 权莉[1] 全燕[1] 汤海瑜 冯小玲[1] 

机构地区：[1]南华大学教学医院广东省第二人民医院,广东广州510317

出　　处：《中国优生与遗传杂志》2015年第1期37-38,50,共3页Chinese Journal of Birth Health & Heredity

基　　金：广东省科技计划项目 项目编号:20120313

摘　　要：目的探讨早期自然流产绒毛染色体异常发生率与孕妇年龄、自然流产次数、流产儿性别、孕周的关系。方法对2013年1月-2014年2月期间广东省第二人民医院就诊的55例自然流产患者行绒毛染色体检查,分析孕妇年龄、自然流产次数、流产儿性别及孕周对绒毛染色体异常发生率的影响。结果绒毛染色体核型正常39例,异常16例,检出率29.1%;孕妇年龄大于30岁组染色体异常发生率明显高于年龄小于等于30岁组(P≤0.05,差异有统计学意义);55例自然流产组织中检出男性胚胎共34例,占61.8%,且男性胚胎染色体异常率(32.4%)高于女性胚胎(23.8%),但差异无统计学意义;既往有自然流产病史的患者染色体异常发生率高于首次发生自然流产者,孕周大于9周者绒毛染色体异常发生率也较高,但差异无统计学意义。结论染色体异常是早期自然流产的重要原因,孕妇高龄可能会使胚胎染色体异常的发生几率增高。自然流产患者清宫时行绒毛染色体检查,明确本次流产绒毛染色体核型,对指导下一次妊娠和优生有重要意义。Objective： To investigate the relationship between the incidence of chromosome aberrations in chorionic villus and age of pregnant women, number of spontaneous abortions, the sexuality of aborted fetus, gestational age. Methods： Our objects were women with spontaneous abortion in Guangdong NO.2 Provincial People＇ s Hospital during the period of January 2013 to February 2014, who asked for villi chromosome examination. We analyzed the influence of age of pregnant women, number of spontaneous abortions, the sexuality of aborted fetus and gestational age on the incidence of chromosomal abnormalities. Results： There were 39 cases of normal villi chromosome karyotype and 16 cases of abnormal villi chromosome karyotype, the abnormal detection rate was 29.1%. The incidence of chromosomal abnormalities in older pregnant women （age〉30） was higher than those of younger （P≤0.05, the difference was statistically significant） . We detected 34 cases of male embryos, accounted for 61.8%, and chromosome abnormality rate in male embryos was 32.4%, than 23.8% in female embryos, but there was no statistically significant difference. We also observed that the incidence of chromosomal abnormalities in patients with recurrent spontaneous abortion is higher, but there was no statistically significant difference. Additionally, gestational age has no obvious relation with viUi chromosome abnormality rate. Conclusion： Chromosome abnormality maybe one of the important reasons of early spontaneous abortion. Pregnant women with older age may increase the risk of embryo chromosomal abnormalities. So it is necessary that Patients with spontaneous abortion to make a villi chromosome examination. If we know the chromosome karyotype of abortion villus, we can better guide the next pregnancy. And we believe that it has an important significance for birth health.

关 键 词：自然流产 绒毛 染色体核型 荧光原位杂交 染色体非整倍体 

分 类 号：R714.21[医药卫生—妇产科学]