兰索拉唑联合中药治疗脾胃湿热型慢性糜烂性胃炎的临床疗效分析  

Clinical Study on Lansoprazole Combined with Traditional Chinese Medicine in the Treatment of Spleen and Stomach Dampness-heat Chronic Erosive Gastritis

作　　者：张晓彤[1] 张丽娟[1] 尹利顺 丁振[1] 赵庆华[1] 孙蓉[2] 曹志群[1] 

机构地区：[1]山东中医药大学,山东济南250014 [2]山东省中医药研究院,山东济南250014

出　　处：《中国药物评价》2014年第6期366-369,共4页Chinese Journal of Drug Evaluation

基　　金：芪莲舒痞颗粒逆转慢性萎缩性胃炎癌前病变机理的研究(30973826);国家重大新药创制科技重大专项课题:中药复方药理学研究及药效学评价关键技术(2009ZX09502-015);山东省中医药科学技术研究项目:内镜下胃粘膜疾病的辨证规律研究(2009097)

摘　　要：目的:观察兰索拉唑联合中药治疗脾胃湿热型慢性糜烂性胃炎的临床疗效。方法:将临床诊断为脾胃湿热型慢性糜烂性胃炎患者91例,随机分为兰索拉唑对照组、中药对照组和兰索拉唑联合中药治疗组(以下简称联合用药组),对照组每组30例,联合用药组31例,对比观察分析疗效差异。结果:联合用药组总有效率为96.8%,兰索拉唑对照组和中药对照组总有效率分别为86.7%和80.0%,联合用药组临床治疗效果明显优于对照组,两组差异有统计学意义。联合用药组可明显改善证候,有效促进黏膜糜烂受损修复,缓解临床症状。结论:兰索拉唑联合中药治疗脾胃湿热型慢性糜烂性胃炎疗效明显优于单一用药治疗,值得临床推广应用。使用中应加强对联合用药指征、用法、疗程的深入研究,以确保联合用药的合理性和有效性。Objective：To investigate the clinical effect of lansoprazole combined with traditional Chinese medicine for treating spleen and stomach dampness-heat of chronic erosive gastritis. Methods： 91 patients were randomly divided into control groups （two groups, each group of 30 cases） and treatment group （ one group,31 cases）. The treatment group took lansoprazole and herbs, the control group 1 took lansoprazole, the control group 2 took herbs. The clinical effects of the three groups were compared. Results： The total effective rate of the treatment group was higher than that of the control groups （96. 8% vs 86.7% 80. 0%, P 〈0. 05）. There was statistical signifi- cance between the data. Conclusion： The efficacy of lansoprazole combined with traditional Chinese medicine can be effective in the treatment of spleen and stomach dampness-heat of chronic erosive gastritis, be worth to popularize, which should strengthen the in-depth study of syndrome, usage, course of treatment of combination therapy, in order to ensure the rationality and validity of the combined use of drugs.

关 键 词：兰索拉唑 中药 脾胃湿热 慢性糜烂性胃炎 

分 类 号：R573.3[医药卫生—消化系统]