三种标本四种肿瘤标记物联合检测卵巢癌的诊断价值探讨  

The Value of Combinative Detection of Three Spcimens And Four Tumor Markers In the Diagnosis of Malignant Ovarian Tumor

作　　者：苗利平[1] 赵敏[1] 严宗哲[2] 徐丛剑[3] 

机构地区：[1]山西省妇幼保健院,山西太原030013 [2]山西医科大学,山西太原030012 [3]复旦大学附属妇产科医院,上海200011

出　　处：《实用妇产科杂志》2002年第4期217-218,共2页Journal of Practical Obstetrics and Gynecology

摘　　要：目的 :为研究提高多种标本多种肿瘤标记物对卵巢癌的诊断性能。方法 :19例卵巢恶性肿瘤患者作为研究组与 19例良性肿瘤患者及 19例正常妇女进行对比。采集血清、唾液、尿三种标本进行 CA1 2 5、癌胚抗原 (CEA)、铁蛋白 (F)及脂链唾液酸 (L SA)四种肿瘤标记物的检测。结果 :三种标本、四种肿瘤标记物的 12项检测指标中 8项 ,恶性组与良性组及正常对照组间差异有显著性 (P<0 .0 1) ,可作为肿瘤标记物 ,并且有较好的诊断性能。结论 :采用不同标本、多项指标的肿瘤标记物检测可提高对卵巢恶性肿瘤诊断的敏感性。Objectives:To improve the value of multiple specimens and tumor markers in the dignosis of malignant ovarian tumor.Methods:19 cases of malignant ovarian tumor were compared with 19 cases benign ovarian tumor and 19 cases healthy woman.Three speaimens including serum,sialism,urine were collected to detected four tumor markers:CA 125?CEA?F?LSA.Results:Of 12 detected indexes about three specimens and four tumor markers,8 indexes of the panel of malignant ovarian tumor were significantly different with those of benign ovarian tumor and those of healthy women,which can act as tumor markers and have a better diagnositic capability.Conclusions:To detect different specimens and multiple tumor markers can improve the sensitivity,specificity and accuracy in the diagnosis of malignant ovarian tumor.

关 键 词：卵巢癌 肿瘤标记物 诊断 CA125 癌胚抗原 铁蛋白 脂链唾液酸 

分 类 号：R737.310.4[医药卫生—肿瘤]