白芷饮片超微粉碎规律的初步探索  

Preliminary Exploration on Ultrafine Grinding Rules of Angelicae Dahuricae Radix Pieces

作　　者：杨迎光[1] 张芳[1] 韩丽[1] 张定堃[1] 唐宜轩 杨明[1,2] 

机构地区：[1]成都中医药大学中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都611137 [2]江西中医药大学现代中药制剂教育部重点实验室,南昌330004

出　　处：《中国实验方剂学杂志》2015年第2期24-26,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:研究白芷饮片的超微粉碎规律。方法:制备白芷细粉及超微粉Ⅰ,Ⅱ,Ⅲ,Ⅳ,考察各粉末的粒径分布、润湿性、红外光谱、吸湿性。采用HPLC测定欧前胡素含量,流动相甲醇-水(70∶30),检测波长251 nm,评价不同白芷粉末的溶出度。结果:白芷细粉的粒径最大,超微粉Ⅳ粒径最小;细粉的润湿性最差,超微粉碎后吸湿性显著改善,超微粉Ⅳ的润湿性最好,接触角趋近零;5种粉末的红外光谱与吸湿性相似度极高;超微粉Ⅲ的溶出度较优。结论:与白芷细粉相比,4种超微粉的化学成分未发生改变,但粉体学性质存在差异,提示超微粉碎药材时应根据具体应用情况选择适宜粒径。Objective：To investigate uhrafine grinding rules of Angelicae Dahuricae Radix pieces.Method：Fine powder and uhrafine powder Ⅰ,Ⅱ,Ⅲ,Ⅳ of Angelicae Dahuricae Radix were prepared,size distribution,wettability,infrared spectrum and moisture absorption were used to evaluate these powders.HPLC was employed to determine the content of imperatorin and evaluate dissolution with methanol-water （70∶ 30） as mobile phase and detection wavelength at 251 nm.Result：Particle size of ordinary powder was the maximum and ultrafine powder Ⅳ was the minimum.Wettability of ordinary powder was the worst,but it improved significantly after being uhrafine ground.Wettability of ultrafine powder Ⅳ was the best and its contact angle approached zero.Infrared spectrum and moisture absorption of these five kinds of powders were extremely similar,dissolution of uhrafine powder Ⅲ was better than others.Conclusion：Chemical compositions in four kinds of ultrafine powders do not change by comparing with ordinary powder,while their micromeritic properties are difference,it shows that ultrafine grinding of herbs should choose appropriate particle size acorrding to specific application.

关 键 词：白芷 超微粉碎 物理表征 溶出度 欧前胡素 

分 类 号：R283.6[医药卫生—中药学] R282.4[医药卫生—中医学]