miR-34b/c启动子区基因多态性与肿瘤易感性的Meta分析  

Roles of polymorphism in promoter region of miR-34b/c in cancer： a Meta analysis

作　　者：曾慧[1] 曾拓[2] 龙行华[1] 

机构地区：[1]武汉大学中南医院检验科,430071 [2]贵州师范大学生命科学院

出　　处：《国际肿瘤学杂志》2015年第1期27-31,共5页Journal of International Oncology

基　　金：国家自然科学基金（30873044、81272372）;教育部留学回国人员科研启动基金（教外司留[2011]1139号）

摘　　要：目的 探讨微小RNA-34b/c（miR-34b/c）启动子区基因多态性与肿瘤易感性的关系.方法 全面检索PubMed、EMBASE、万方、维普和中国知网等中英文数据库,纳入符合标准的病例对照研究,运用RevMan 5.1软件对数据进行合并分析.结果 总共纳入9篇文献10项病例对照研究,Meta分析结果显示miR-34b/c启动子区基因多态性与肿瘤在CvsT、CC vs TT、CC＋ CT vs TT以及CC vs CT＋ TT这4种模型分析中易感性无明显相关性,但在CT vs TT模型分析中,结果显示出显著的相关性（Z=2.33,P=0.02）.根据肿瘤的类型进行亚组分析发现,在肝细胞肝癌,Cvs T（Z =2.10,P=0.04）、CT vsTT（Z＝2.40,P =0.02）以及CC ＋CT vs TT（Z =2.45,P=0.01）模型中相关性均具有统计学意义.C等位基因明显增加了肝癌的易感性（OR=1.11,Z=2.10,P=0.04）,但在结直肠癌的研究中发现,在CC vsTT和CC vs CT＋ TT模型中,CC基因型能显著降低结直肠癌的易感性,OR值分别为0.66 （Z =2.43,P=0.02）、0.67（Z=2.40,P=0.02）.结论 miR-34b/c启动子区基因多态性rs4938723 T＞C与肝癌和结直肠癌的易感性存在一定的相关性.Objective To investigate the association between the genetic variant in the promoter region of miR-34b/c and cancer risk.Methods Databases such as PubMed、EMBase、Wanfang、VIP、CNKI and so on were searched comprehensively.Based on the including and excluding criteria,literatures that were eligible were screened and data were retrieved.Meta analysis was performed by RevMan 5.1 software.Results Through searching and manually searching relevant references,a total of 9 articles with 10 independent studies were included.No significant associations were detected in C vs T,CC vs TT,CC ＋ CT vs TT and CC vs CT ＋ TT comparison models.However,in the CT vs TT comparison model,the result showed a significant association （Z =2.33,P =0.02）.Meanwhile,subgroup analysis of hepatocellular carcinoma and colorectal cancer both showed significant associations with the polymorphism,with C vs T （OR =1.11,Z =2.10,P =0.04）,CT vs TT （Z=2.40,P =0.02）,CC ＋CT vs TT （Z=2.45,P=0.01） and CC vs TT （OR =0.66,Z=2.43,P=0.02）,CC vs CT ＋ TT （OR =0.67,Z =2.40,P =0.02） respectively.The C allele increased significantly the susceptibility of hepatocellular carcinoma,and the CC genotype reduced significantly the susceptibility of colorectal cancer.Conclusion The genetic variant in the promoter region of miR-34b/c rs4938723 T ＞ C is significantly associated with the susceptibility of hepatocellular carcinoma and colorectal cancer.

关 键 词：肿瘤 多态现象 遗传 META分析 miR-34b/c 

分 类 号：R730.2[医药卫生—肿瘤]