缝隙连接与神经病理性痛的研究进展  

Recent research progress on the role of gap junction in neuropathic pain

作　　者：彭力超[1] 梁尚栋[1] 

机构地区：[1]南昌大学基础医学院生理学教研室,江西南昌330006

出　　处：《中国药理学通报》2015年第2期157-162,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81171184;31060139;30860086);第二批江西省"赣鄱英才555工程"领军人才项目;江西省自然科学基金资助项目(No20142BAB205028);江西省教育厅科技项目(NoGJJ13155)

摘　　要：缝隙连接是介导相邻细胞间物质转运、化学或电信号传递的专用跨膜通道,维持着细胞内环境的稳定。在神经系统中,缝隙连接不仅介导神经元和胶质细胞的胞间偶合,还参与病理条件下继发性损害。目前,研究证明缝隙连接在由神经系统损伤引起的神经病理性痛中发挥作用。对缝隙连接与神经病理性痛的关系进行研究有助于更深层次的了解神经病理性痛的发病机制,为治疗神经病理性痛提供新的研究方向。Gap junctions are specialized transmembrane channels that enable the direct exchange of materials and transfer chemical or electrical signaling between adjacent cells,thus maintaining cellular homeostasis. In the nervous system,gap junction channels not only mediate intercellular coupling between neurons and between glial cells,but also can be involved in secondary damage under pathological conditions. Recently,some studies have shown that gap junctions play an important role in neuropathic pain caused by nervous system damage. Research on the role of gap junctions in neuropathic pain can contribute to a deeper understanding of the pathogenesis of neuropathic pain,providing a new research direction for the treatment of neuropathic pain.

关 键 词：缝隙连接 连接蛋白 神经系统 胶质细胞 神经病理性痛 缝隙连接阻断剂 

分 类 号：R05[医药卫生] R322.8