血小板介导肿瘤血行转移的作用及其机制研究进展  

Research progress on the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms

作　　者：曹玉珠[1] 刘兆国[1] 单云龙[1] 孙丽华[1] 刘玉萍[1] 韦忠红[1] 祝娉婷[1] 吴红雁[1] 王爱云[1] 陈文星[1] 郑仕中[1,2] 陆茵[1,2] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]江苏省中药药效与安全性评价重点实验室,江苏南京210023

出　　处：《中国药理学通报》2015年第2期166-169,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81173174;81202655);教育部博士点基金资助项目(No 20113237110008);江苏省普通高校研究生科研创新计划项目(No KYLX_0972;KYZZ_0270)

摘　　要：肿瘤转移是恶性肿瘤最为重要的生物学特性之一,同时也是影响预后及导致治疗失败的主要因素。临床研究显示,恶性肿瘤患者的血小板数目较正常人及良性肿瘤患者明显升高,表明血小板可能参与了肿瘤的发生发展过程。进一步研究发现,血小板在肿瘤血行转移的过程中能够与肿瘤细胞相互作用形成瘤栓,逃避免疫监视,进而促进了肿瘤的转移。近年来,临床上已经开展了针对血小板治疗肿瘤转移的研究,同时,血小板促进肿瘤转移的相关作用机制也逐步地被揭示。该文对近年来血小板介导肿瘤血行转移的作用及其作用机制研究进展进行综述,探讨临床针对血小板治疗肿瘤转移的策略,为后续的科学研究及指导临床提供参考。Tumor metastasis is one of the most important biological characteristics of malignant tumor,and it is also the main factors that cause treatment failure and poor prognosis. Clinical studies have shown that the number of platelets in patients with malignant tumor increased more significantly than that in benign tumor patients and healthy people,which indicate that platelet might be involved in the development process of tumor. Further study found that in the process of cancer spreading to blood,platelet could interact with tumor cells to form tumor emboli,helped tumor cells escape from immune surveillance,thus promoted the tumor metastasis. In recent years,related mechanisms on platelets in promoting tumor metastasis were revealed gradually,and several targeted therapies based on platelets were also carried out. This paper reviews the role of platelet in mediating tumor metastasis by hematogenous spread and its mechanisms and discusses the therapy strategies that target platelet,which may provide references for follow-up research and clinical treatment.

关 键 词：血小板 瘤栓 肿瘤血行转移 分子机制 治疗策略 临床应用 

分 类 号：R-05[医药卫生] R331.124