不同熔附金属全冠对种植体周围组织中炎症因子、黏附分子、OPG/RANKL表达的影响  

Influences of different fused metal crown on inflammatory cytokines,adhesion molecules,OPG/RANKL expression in tissue around implant

作　　者：陈昊[1] 曹直[1] 王亚玲[1] 赵春光[1] 赵会琴[1] 陈敏[1] 刘志云[1] 

机构地区：[1]江汉大学附属医院口腔科,湖北武汉430015

出　　处：《海南医学院学报》2015年第2期278-280,283,共4页Journal of Hainan Medical University

基　　金：武汉市卫生局临床医学科研项目(WZ13A02)~~

摘　　要：目的:研究不同熔附金属全冠对种植体周围组织中炎症因子、黏附分子、OPG/RANKL表达的影响。方法:选取在本院接受熔附金属全冠修复的90例患者纳入研究,包括镍铬合金修复、钴铬合金修复、金合金修复各30例,分别纳入镍铬合金组、钴铬合金组和金合金组,检测龈沟液中炎症因子、黏附分子、OPG/RANKL的表达情况。结果:(1)炎症因子:镍铬合金组龈沟液中白细胞介素-6(IL-6)、NO以及基质金属蛋白酶-2(MMP-2)含量均高于钴铬合金组和金合金组,差异具有统计学意义(P<0.05);(2)黏附分子:镍铬合金组龈沟液中可溶性细胞间黏附分子-1(sICAM-1)、可溶性血管黏附分子-1(sVCAM-1)、E型钙粘附分子(E-cadherin)含量均高于钴铬合金组和金合金组,差异具有统计学意义(P<0.05);(3)OPG/RANKL:镍铬合金组患者的RANKL含量、RANKL/OPG比例低于钴铬合金组和金合金组,OPG含量高于钴铬合金组和金合金组,差异具有统计学意义(P<0.05)。结论:钴铬合金和金合金熔附金属全冠对牙周组织的刺激较弱,龈沟液中炎症因子、黏附分子含量以及OPG/RANKL比例较低。Objective： To investigate the influences of different fused metal crown on inflammatory cytokines, adhesion molecules, OPG/RANKL expression in tissue around implant. Methods： A total of 90 patients received fused metal crown res toration in our hospital were enrolled and divided into three groups including Ni Cr alloy group, CO-Cr alloy group and gold al- loy group, which underwent Ni-Cr alloy repair, CO-Cr alloy repair, gold alloy repair, respectively, with 30 cases in each group. Then expression of inflammatory cytokines, adhesion molecules, OPG/RANKL in gingival sulcus fluid were detected and compared. Results： （1） Inflammatory cytokines： IL-6, NO and MMP2 content of Ni-Cr alloy group were higher than those of CO-Cr alloy group and gold alloy group; （2） adhesion molecules： sICAM-1, sVCAM-1, E-cadherin content Ni-Cr alloy group were higher than those of CO-Cr alloy group and gold alloy group; （3）OPG/RANKL： RANKL content and RANKL/OPG ratio of Ni-Cr alloy group were higher than those of CO-Cr alloy group and gold alloy group; OPG contents were lower than those of CO-Cr alloy group and gold alloy group. Conclusion： The stimulation of Co-Cr alloy and gold alloy fused metal crown are weaker, inflammatory eytokines, adhesion molecules, OPO/RANKL in gingival crevicular fluid are lower.

关 键 词：熔附金属冠 炎症因子 黏附分子 破骨细胞核心因kB受体活化因子配基 骨保护因子 

分 类 号：R783[医药卫生—口腔医学]