间充质干细胞在肝脏疾病应用的研究现况  

Advances in treatment of liver disease with mesenchymal stem cells

作　　者：金银鹏[1] 傅青春[1] 陈成伟[1] 

机构地区：[1]解放军第八五医院上海南京军区临床肝病中心,上海200235

出　　处：《中华细胞与干细胞杂志（电子版）》2014年第4期51-56,共6页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：间充质干细胞(MSC)属于成体干细胞的一种,是一类具有自我更新和多向分化能力的多能干细胞。其来源丰富,免疫原性低,目前体内外实验均发现MSC可促进损伤肝脏修复,改善症状,提高存活率。通过调节肝脏局部和全身炎症反应和免疫紊乱发挥治疗作用。本文就MSC治疗肝脏疾病的研究现况进行综述。Mesenchymal stem cell（MSC） are adult stem cells with self-renewal and multipotent differentiation capacity. Rich source and low immunogenicity of MSC enable their clinical application for damaged liver tissue. Improvement of symptoms and survival rate of patients has been observed. MSC play a therapeutic role in liver diseases by modulating local and systemic inflammatory response and immune dysfunction. This review focuses on the current status of MSC in treating liver diseases.

关 键 词：间充质干细胞 肝病 机制 

分 类 号：R575[医药卫生—消化系统]