非酒精性脂肪肝相关危险因素分析  

Analysis of related risk factors of non-alcoholic fatty liver disease

作　　者：胡红心[1] 周建英[2] 

机构地区：[1]南京医科大学附属苏州医院检验科,215001 [2]南京医科大学附属苏州医院内分泌科,215001

出　　处：《中国实用医药》2014年第35期5-6,共2页China Practical Medicine

摘　　要：目的分析非酒精性脂肪肝(NAFLD)患者临床指标,探讨其相关危险因素。方法 180例体检患者按有无NAFLD分为正常对照组(86例)和NAFLD组(94例),对两组各临床指标进行统计分析。结果与对照组比较,NAFLD组体质量指数(BMI)、腰围、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ-谷氨酰转肽酶(GGT)、血脂总胆固醇(TC)、甘油三酯(TG)、非高密度脂蛋白胆固醇(non-HDL-C)、空腹血糖(FBG)、尿酸、收缩压(SBP)、舒张压(DBP)均显著升高,而高密度脂蛋白胆固醇(HDL-C)显著降低(P<0.05)。Logistic回归分析显示BMI、腰围、TG可较好地预测NAFLD,是NAFLD的独立危险因素(P<0.05)。结论 NAFLD患者具有中心性肥胖、高血糖、高血压、脂代谢紊乱(高TC、高TG、低HDL-C)、高尿酸的特征,且肝酶升高。BMI、腰围、TG是发生NAFLD的独立危险因素。Objective To analyze the clinical index of patients with non-alcoholic fatty liver disease （NAFLD）, and to explore its related risk factors.Methods A total of 180 physical examination patients were divided into normal control group （86 cases） and NAFLD group （94 cases）, according to their condition of having NAFLA or not. The clinical indexes were statistically analyzed in the two groups.Results Compared with the control group, the levels of body mass index （BMI）, waistline, alanine aminotransferase （ALT）, aspartate transaminase （AST）, γ-gamma glutamyl transpeptidase （GGT）, total cholesterol （TC）, triglyceride （TG）, non high density lipoprotein cholesterol （non-HDL-C）, fasting blood glucose （FBG）, uric acid, systolic blood pressure （SBP）, and diastolic blood pressure （DBP） were significantly increased in the NAFLD group, and the level of high-density lipoprotein cholesterol （HDL-C） was decreased obviously （P〈0.05）. Logistic regression analysis indicated that BMI, waistline, and TG level could effectively predict NAFLD, and they were the independent risk factors of NAFLD （P〈0.05）.Conclusion NAFLD patients have the features of central obesity, hyperglycemia, hypertension, dyslipidemia （high levels of TC and TG, low level of HDL-C）, hypeluricemia, and elevated liver enzymes. The independent risk factors of NAFLD are BMI, waistline and TG.

关 键 词：非酒精性脂肪肝 危险因素 体质量指数 代谢综合征 

分 类 号：R575.5[医药卫生—消化系统]