丘脑卒中伴嗜睡患者血浆下丘脑分泌素和白细胞介素-17含量变化  

Changes of Hypocretin and Interleukin 17 in Plasma of Thalamic Stroke with Sleepness

作　　者：田倩倩[1,2] 崔林阳[1] 薛蓉[1] 

机构地区：[1]天津医科大学总医院神经内科,天津300052 [2]潍坊医学院附属医院神经内科

出　　处：《中国卒中杂志》2015年第1期22-26,共5页Chinese Journal of Stroke

基　　金：天津市重点攻关项目(12KG132);天津市科技支撑项目资助(13ZCZDSY01900)

摘　　要：目的了解急性丘脑卒中伴嗜睡患者血浆中下丘脑分泌素（hypocretin,Hcrt）及白细胞介素-17（interleukin 17,IL-17）的变化,探索丘脑卒中炎性反应的发生机制。方法选择2013年3月-2014年3月在天津医科大学总医院神经内科住院的经头颅影像学检查证实的急性丘脑卒中的患者34例为研究对象,按有无嗜睡的发生将其分为丘脑卒中伴嗜睡组（18例）和丘脑卒中不伴嗜睡组（16例）,检测两组患者血浆中Hcrt、IL-17水平的差异,观察比较急性期丘脑卒中睡眠障碍血浆中Hcrt和炎性因子的改变。结果丘脑卒中伴嗜睡组Hcrt水平较不伴嗜睡组增高,P=0.001。丘脑卒中伴嗜睡组IL-17水平较不伴嗜睡组增高,P=0.001。结论 Hcrt可能是丘脑卒中后睡眠-觉醒障碍的一个敏感的生化指标,IL-17可能参与了急性丘脑卒中睡眠障碍炎性病理机制的发生过程。Objective To evaluate the changes of hypocretin and interleukin 17（IL-17） in serum and to examine the mechanism underlying inflammatory reaction of acute thalamic stroke. Methods We measured the level of hypocretin and IL-17 in the serum of 34 patients who suffered acute stroke during Tianjin Medical University General Hospital between March 2013 and March2014.The patients can be divided into two groups according to with or without somnolence. Results Compared with thalamic stroke without somnolence group,the level of hypocretin in thalamic stroke with somnolence was higher（P=0.001）.Significant differences were also found in the level of IL-17.The level of IL-17 was higher in thalamic stroke with somnolence group than in thalamic stroke without somnolence group（P=0.001）. Conclusion The level of hypoctetin may be a sensitive biochemical for sleep disorder after thalamic stroke,suggesting that IL-17 may participate in the pathogenesis of the inflammatory process in acute thalamic stroke patients with sleep disorders.

关 键 词：丘脑 卒中 下丘脑分泌素 白细胞介素 睡眠-觉醒障碍 

分 类 号：R743[医药卫生—神经病学与精神病学]