急性缺血性脑卒中患者幽门螺杆菌感染与CRP、PCT关系探讨  

Relationship of helicobacter pylori infection with C-reactive protein and procalcitonin in patients with acute ischemic stroke

作　　者：管琼峰[1] 孙苓嘉 范伟女[1] 

机构地区：[1]浙江省宁波市第二医院神经内一科,315010

出　　处：《中华全科医学》2015年第2期193-195,共3页Chinese Journal of General Practice

摘　　要：目的探讨急性缺血性脑卒中患者的幽门螺杆菌(HP)感染状况及其与C-反应蛋白(CRP)、降钙素原(PCT)在急性缺血性脑卒中临床上的意义。方法分析2012年7月—2014年1月在宁波市第二医院神经内科接受治疗的急性缺血性脑卒中患者的临床资料。将入组的急性缺血性脑卒中患者作为观察组,都在发病7 d内入院,对照组选择同期门诊的健康体检者。入院治疗次日上午、对照组在体检当天抽取9 ml的肘正中静脉血,分别检测患者的CRP、PCT及HP抗体。比较2组患者的一般资料、Hp感染状况以及Hp感染状况与CRP、PCT的相关性。结果本研究共纳入研究对象150例,其中观察组患者77例,对照组73例,2组受试者的基线资料差异无统计学意义(P>0.05);观察组患者的Hp-Ig G阳性率(χ2=11.72,P<0.01)、Hp-CIM阳性率(χ2=9.770,P<0.01)均显著高于对照组;Hp现症感染患者[Hp-CIM阳性组,(7.8±1.8)mg/L]、Hp既往感染者[Hp-Ig G阳性组,(5.4±1.3)mg/L]及正常对照组[(2.2±0.6)mg/L]所对应的CRP水平比较结果差异具有统计学意义(F=305.3,P<0.01),且Hp-CIM阳性组患者最高,正常对照组最低;Hp现症感染患者[(1.9±0.7)ng/ml]、Hp既往感染者[(1.4±0.3)ng/ml]及正常对照组[(0.3±0.1)ng/ml]所对应的PCT水平比较结果提示差异具有统计学意义(F=305.3,P<0.01),且Hp-CIM阳性组患者最高,正常对照组最低。结论缺血性脑卒中与Hp感染关系密切,而Hp感染状况与CRP和PCT有着一定的相关性。Objective To investigate the prevalence of Helicobacter pylori（ H. pylori） in patients with acute ischemic stroke,and discuss the role of C-reactive protein（ CRP） and procalcitonin（ PCT） in acute ischemic stroke. Methods The clinical data of 77 cases of acute ischemic stroke（ observe group） and 73 individuals in in physical examination（ control group） in our hospital from July,2012 to January,2014 were reviewed retrospectively. The blood sample from the median cubital vein was prepared at admission for the test of CRP,PCT and Hp-Ig G. The general information,prevalence of Helicobacter pylori,relationship between H. pylori infection and the levels of CRP and PCT were compared between two groups. Results There was no obvious difference in baseline information between the two groups（ P〈0. 05）; The positive rate of Hp-Ig G（ χ^2= 11. 72,P〈0. 01） and Hp-CIM（ χ^2= 9. 770,P〈0. 01） in the observe group was significantly higher than those in control group. The levels of CRP were（ 7. 8 ± 1. 8） mg / L in the observe group（ positive Hp-CIM）,（ 5. 4 ± 1. 3） mg/L in the patients with previous Hp infection（ positive Hp-Ig G）,and（ 2. 2 ± 0. 6） mg/L in the control group,the difference was statistical significant（ F = 305. 3,P〈0. 01）; The levels of PCT were（ 1. 9 ± 0. 7） ng / ml in the patients with H. pylori infection,（ 1. 4 ± 0. 3） ng / ml in the patients with previous Hp infection,and（ 0. 3 ± 0. 1） ng / ml in the control group,the difference was statistical significant（ F = 305. 3,P〈0. 01）. Conclusion The acute ischemic stroke had a correlation with H. pylori infection,and the H. pylori infection was associated with the level of CRP and PCT.

关 键 词：急性缺血性脑卒中 幽门螺杆菌 C-反应蛋白 降钙素原 

分 类 号：R743.3[医药卫生—神经病学与精神病学]