FoxM1、Cep55和c-Myc蛋白在基底细胞样乳腺癌中的表达及临床意义  

Expressions and clinical significance of Fox M1 and Cep55 in basal-like breast cancer

作　　者：马秋双[1] 周炳娟[1] 张金库[1] 赵文明[1] 赵亚飞[2] 

机构地区：[1]河北省保定市第一中心医院病理科,071000 [2]河北省保定市第一中医院

出　　处：《河北医药》2015年第1期5-9,共5页Hebei Medical Journal

基　　金：河北省卫生厅青年科技课题(编号:201303333)

摘　　要：目的探讨Fox M1、Cep55及c-Myc蛋白在基底细胞样型乳腺癌(BLBC)中的表达及临床意义。方法采用免疫组化方法检测66例BLBC、70例NON-BLBC和66例癌旁正常乳腺组织中Fox M1、Cep55及c-Myc蛋白的表达情况及三者间的相互关系。结果 Fox M1蛋白在BLBC、NON-BLBC和癌旁正常乳腺组织中的阳性表达率分别为77.3%(51/66)、60.0%(42/70)、13.6%(9/66),Cep55蛋白在BLBC、NON-BLBC和癌旁正常乳腺组织中的阳性表达率分别为74.2%(49/66)、57.1%(40/70)、16.7%(11/66),c-Myc蛋白在BLBC、NON-BLBC和癌旁正常乳腺组织中的阳性表达率分别为71.2%(47/66)、54.3%(38/70)、22.7%(15/66),差异均有统计学意义(P<0.05)。Fox M1、Cep55及c-Myc蛋白的表达与BLBC的TNM分期及淋巴结转移情况密切相关(P<0.05),而与年龄、绝经与否、肿块大小无关(P>0.05)。Fox M1和Cep55蛋白在BLBC中的表达呈正相关关系(P<0.05),Fox M1和c-Myc蛋白在BLBC中的表达呈正相关关系(P<0.05),而Cep55与c-Myc的表达没有相关性(P>0.05)。结论 Fox M1、Cep55及c-Myc蛋白可能参与了BLBC的发生、发展,并且Fox M1分别与Cep55及c-Myc在BLBC发生发展过程中可能有一定的协同作用;Cep55蛋白与c-Myc蛋白在BLBC中的表达没有相关性,说明Cep55及c-Myc可能通过不同的作用对BLBC的发生发展过程产生影响。Objective To detect the expression of Fox M1,Cep55 and c-Myc in basal-like breast carcinoma（ BLBC）.Methods The expression levels of Fox M1,Cep55 and c-Myc were detected by immunohistochemisty in 66 cases of BLBC,70 cases of non-BLBC and 66 cases of normal breast tissues beside carcinoma. Results The positive expression rate of Fox M1 was 77. 3%（ 51 /66）,60. 0%（ 42 /70）,13. 6%（ 9 /66）,respectively in BLBC tissues,non-BLBC tissues and BLBC adjacent tissues,respectively. The positive expression rate of Cep55 was 74. 2%（ 49 /66）,57. 1%（ 40 /70）,16. 7%（ 11 /66）,respectively in the three kinds of tissues. The positive expression rate of c-Myc was 71. 2%（ 47 /66）,54. 3%（ 38 /70）,22. 7%（ 15 /66）,respectively in the three groups,there were significant differences in the positive expression rates among them（ P〈0. 05）.（ 2） The expression of Fox M1,Cep55 and c-Myc was closely correlated to TNM staging and lymph node metastasis of BLBC（ P〈0. 05）,however,which was not related with patient＇s age,whether menostasis or not,tumor＇s size in patients with BLBC（ P〈0. 05）.（ 3） The expression of Fox M1 was positively correlated to that of Cep55 in BLBC（ P〉0. 05）,so was the expression of Fox M1 to that of c-Myc in BLBC（ P〈0. 05）,however,the expression of Cep55 was not related with that of c-Myc（ P〉0. 05）. Conclusion Fox M1,Cep55 and c-Myc may be involved in the carcinogenesis and development of BLBC,and Fox M1 and Cep55 may affect the process of carcinogenesis and development of BLBC through different ways.

关 键 词：FOX M1蛋白 Cep55蛋白 C-MYC蛋白 基底细胞样乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]