DC-CIK治疗对辅助化疗后三阴乳腺癌的临床疗效观察  

Clinical Effect of DC-CIK in Treatment of Three Negative Breast Cancer after Adjuvant Chemotherapy

作　　者：朱欢欢[1] 马东初[2] 丁震宇[1] 韩涛[1] 郭放[1] 刘兆喆[1] 韩雅玲[3] 谢晓冬[1] 

机构地区：[1]沈阳军区总医院全军肿瘤诊治中心肿瘤科,沈阳100840 [2]沈阳军区总医院全军肿瘤诊治中心医学实验科,沈阳100840 [3]沈阳军区总医院全军心血管病研究所,沈阳100840

出　　处：《解放军医药杂志》2015年第1期48-51,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：科技部十二五重大新药创制平台子课题(2012ZX09303016-002);2012年辽宁省科技攻关计划课题(2012225019)

摘　　要：目的探讨自体DC-CIK细胞免疫治疗对辅助化疗后三阴乳腺癌的临床疗效。方法收集2003年1月—2012年11月收治65例术后明确诊断三阴乳腺癌的患者,术后完成相应周期的辅助化疗后1-2个月后37例作为观察组给予体外培养自体DC-CIK细胞治疗。28例作为对照组进行定期随访。观察DC-CIK细胞免疫治疗前后各肿瘤标志物、免疫指标、化疗相关毒性反应、生存质量及生存期的变化。结果观察组治疗前后各肿瘤标志物（CEA、CA15-3）、免疫指标（CD3、CD4、CD8）比较差异无统计学意义（P〉0.05）;两组相关毒性反应（疲乏无力、恶心呕吐、情志抑郁、失眠）差异均有统计学意义（P〈0.05）。结论 DC-CIK细胞免疫治疗为辅助化疗后三阴乳腺癌治疗提供新的治疗方法,可缓解化疗相关毒性反应,改善生活质量、延长总生存期。Objective To explore clinical effect of autologous DC-CIK（ dendritic cell-cytokine-induced killer）cells immunotherapy on three negative breast cancer after adjuvant chemotherapy. Methods Clinical data of 65 postoperative patients with three negative breast cancer during January 2003 and November 2012 after surgery were collected.After postoperative corresponding cycles of chemotherapy for 1-2 months,37 patients（ observation group） underwent autologous DC-CIK cells immunotherapy cultured in vitro. The 28 patients（ control group） received regular follow-up. The changes of tumor markers,immunity indexes,the targeting drug-related adverse reactions,quality of life and overall survival rate before and after DC-CIK cells immunotherapy were observed. Results The differences in tumor markers（ CEA and CA15-3）,immunity indexes（ CD3,CD4 and CD8） before and after adjuvant chemotherapy in observation group showed no statistical significances（ P〉0. 05）; while the differences in targeting drug-related toxic reactions（ fatigued and weak,nausea and vomiting,emotional depression and sleeplessness） in the two groups showed statistical significances（ P〈0. 05）. Conclusion DC-CIK cell immunotherapy for three negative breast cancer after adjuvant chemotherapy provides a new therapeutic method,and may relieve targeting drug-related toxic reactions,improve quality of life and prolong overall survival time.

关 键 词：细胞因子诱导杀伤细胞 乳腺肿瘤 化学疗法 辅助 

分 类 号：R737.9[医药卫生—肿瘤]