慢性牙周炎患者翻瓣术后TNF-a水平和牙周临床指数的变化及意义  

Changes and Clinical Significances of TNF-a level and Periodontal Clinical Indices Patients with Periodontal Flap Surgery after Periodontal flap Operation

作　　者：黄涛[1] 刘琳[1] 

机构地区：[1]哈励逊国际和平医院口腔科,河北衡水053000

出　　处：《中国实验诊断学》2015年第1期38-40,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的研究慢性牙周炎患者翻瓣术后TNF-a水平和牙周临床指数的变化及意义。方法选取我院口腔科2012年6月—2013年6月治疗的慢性牙周炎患者80例,按照随机数字表法分为观察组(40例)和对照组(40例)。观察组给予慢性牙周炎翻瓣术治疗,对照组给予慢性牙周炎支持疗法,病变区行龈下刮治和根面平整术,观察两组患者治疗前后血液TNF-a水平和牙周探测深度(PD)、菌斑指数(PLI)、龈钩出血指数(SBI)等牙周临床指标变化情况。结果治疗前两组患者TNF-a、PD、PLI及SBI水平比较差异均无统计学意义(均P>0.5);治疗后两组患者TNF-a、PD、PLI及SBI水平均低于治疗前,但仅观察组差异有统计学意义(均P<0.05);治疗6周后,观察组患者TNF-a、PD、PLI及SBI水平均低于对照组,差异有统计学意义(均P<0.05)。观察组患者治疗前血清TNF-a水平与PD、PLI和SBI之间呈正相关关系(P<0.05),治疗后患者血清TNF-a水平与PD、PLI及SBI之间均无显著的相关性(P>0.05)。结论慢性牙周炎翻瓣术治疗可以明显降低TNF-a水平,并且改善牙周临床指数,同时TNF-a水平及牙周临床指数的变化可以反映牙周炎的治疗效果和病情变化。Objective To explore changes and clinical significances of TNF-（level and periodontal clinical indices patients with periodontal flap surgery after periodontal flap operation.Methods 80 cases of chronic periodontitis were collected who treated in our hospital from June 2012 to June 2013,randomly divided into observer group （40 cases）and control group （40 cases）.The observer group received the treatment of chronic periodontitis flap surgery,the control group received supportive therapy of chronic periodontitis,under the lesion line scaling and root planing,observe blood TNF-a levels and probing depth before and after treatment （PD）,changes in gingival bleeding index hook （SBI）and other clinical periodontal index,plaque index （PLI）.Results Before treatment,TNF-a,PD,PLI and SBI levels were not statistically significant（P〉0.05）;After treatment,TNF-a,PD,PLI and SBI were lower than before treatment,but on-ly experiment group difference was statistically significant（P〈0.5）;after 6 weeks,the observer group TNF-a,PD,PLI and SBI were lower than the control group,the difference was statistically significant（P〈0.05）.Before treatment,the observer group showed a positive correlation between serum（P〈0.05）between the horizontal and the PD,PLI and SBI TNF-a,after treatment,the serum TNF-a levels were not significantly between PD,PLI and SBI correlation（P〉0.05）. Conclusion Chronic periodontitis flap surgery can significantly reduce the level of TNF-a,and improve clinical perio-dontal index,and TNF-a level and periodontal clinical indices of changes can reflect the treatment effect of periodontitis and condition changes.

关 键 词：慢性牙周炎 翻瓣术 TNF-a水平 牙周临床指数 

分 类 号：R781.42[医药卫生—口腔医学]