冠心病微生物感染状况与血清3种炎症标志物的相关性研究  

Study on correaltion between microorganisms infectious status with 3 kinds of inflammatory markers in coronary heart disease

作　　者：沈云峰[1] 胡远贵[1] 张洪波[1] 

机构地区：[1]武汉市第六医院检验科,430015

出　　处：《检验医学与临床》2015年第2期169-171,共3页Laboratory Medicine and Clinic

基　　金：武汉市卫生局临床医学科研项目(WX11B14)

摘　　要：目的探讨冠心病患者肺炎衣原体(CPN)、幽门螺杆菌(Hp)、人类巨细胞病毒(HCMV)3种病原微生物的感染状况与3种血清炎症标志物[超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)]水平的相关性。方法选取2012年7月至2013年12月住院的冠心病患者105例作为冠心病组,同时选择同期住院非冠心病患者76例作为对照组。检测两组CPN、Hp、HCMV 3种微生物的IgG抗体,以及血清中hs-CRP、IL-6和TNF-α浓度。结果冠心病组CPN-IgG、Hp-IgG和HCMV-IgG单阳性、双阳性和三阳性的阳性率分别为33.3%、52.3%、78.1%、41.9%、13.3%,对照组阳性率则分别为14.5%、35.5%、63.2%、23.7%、2.6%,两组的相应阳性率比较差异有统计学意义(P<0.05)。CPN-IgG、Hp-IgG和HCMV-IgG阳性对患冠心病的危险度比值比分别为3.297、2.278、2.352,差异有统计学意义(P<0.05)。随着冠心病的病原体感染负荷增加,3种血清炎症标志物浓度亦增加,每组间差异有统计学意义(P<0.05)。结论冠心病患者存在CPN、Hp、HCMV 3种病原微生物的混合感染,长期反复慢性混合感染与冠心病关系密切,可诱导炎症标志物之间相互协同共同参与冠心病的发生、发展过程。感染性因素是冠心病的独立危险因素,对冠心病的诊断治疗有积极意义。Objective To explore the correlation between the infection status of Chlamydia pneumoniae （CPN） ,Helicobacter pylori（Hp） ,human cytomegalovirus（HCMV） and the levels of serum inflammatory cytokines of high sensitive C‐reactive protein（hs‐CRP） ,interleukin‐6（IL‐6） and tumor necrosis ractor‐α（TNF‐α） in the patients with coronary heart disease（CHD） .Methods 105 inpatients with CHD in our hospital from July 2012 to December 2013 were randomly selected as the CHD group and contemporaneous 76 persons for conducting the healthy examina‐tion were selected as the healthy control group .The serum IgG antibodies of CPN ,Hp and HCMV ;hs‐CRP ,IL‐6 and TNF‐αwere detected .The serum hs‐CRP ,IL‐6 and TNF‐αleves also detected .Results The single ,double and triple positive rates of CPN‐IgG ,Hp‐IgG and HCMV‐IgG in the CHD group were 33 .3% ,52 .3% ,78 .1% ,41 .9% and 13 .3% respectively ;which in the control group were 14 .5% ,35 .5% ,63 .2% ,23 .7% and 2 .6% respectively ,the diferences among them had statistical differences（P〈0 .05） .The risk degrees of positive CPN‐IgG ,Hp‐IgG and HC‐MV‐IgG for suffering from CHD were 3 .297 ,2 .278 and 2 .352 ,the difference had statistical significance（P〈0 .05） . With the increase of pathogenic infection burden in CHD ,the levels of hs‐CRP ,IL‐6 and TNF‐αwere also increased , the diferences among the groups showed statistical significance（P〈0 .05） .Conclusion The mixed infection of CPN , HCMV and Hp exist in the patients with CHD .Their long‐term repeated chronic and mixed infection is closely relat‐ed with CHD ,which could induce the inflammatory markers mutually and synergistically participating in the occur‐rence and development process of CHD .The infectious factor is the independent risk factor and has active significance in the diagnosis and treatment of CHD .

关 键 词：冠心病 肺炎衣原体 幽门螺杆菌 人类巨细胞病毒 超敏C-反应蛋白 白细胞介素-6 肿瘤坏死因子Α 

分 类 号：R-341.4[医药卫生]