乙型肝炎肝硬化患者中医证型与血清NPY的相关性研究  

Hepatitis B patients with cirrhosis of traditional Chinese medicine syndrome and thecorrelation of serum NPY research

作　　者：姜付泉 薛晓琳[1] 王天芳[1] 吴秀艳[1] 葛舰[1] 田露[1] 李昕[1] 赵丰润 赵丽红[1] 王思颖[1] 李宁[1] 李婷婷[1] 李永纲[2] 杨慧银[2] 孙凤霞[3] 江宇泳[3] 刘燕玲[4] 郭朋[4] 陈盛铎[5] 张秋云[6] 李秀惠[7] 毛德文[8] 张厂[9] 刘汶[10] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]解放军第302医院中西医结合肝病诊疗与研究中心,北京100039 [3]首都医科大学附属北京地坛医院,北京100011 [4]中国中医科学院西苑医院,北京100091 [5]湖北省中医院,武汉430061 [6]首都医科大学,北京100013 [7]首都医科大学附属北京佑安医院,北京100052 [8]广西中医药大学第一附属医院,南宁530023 [9]北京中医药大学东方医院,北京100078 [10]首都医科大学附属北京中医医院,北京100010

出　　处：《天津中医药》2015年第1期10-14,共5页Tianjin Journal of Traditional Chinese Medicine

基　　金：国家自然科学青年基金资助项目(81302915);国家重点基础研究发展计划(973计划)项目(2011CB505105);北京中医药大学创新团队项目(2011CXTD08)

摘　　要：[目的]探讨乙型肝炎肝硬化患者的中医证型与血清神经肽(NPY)水平的相关性。[方法]比较代偿期与失代偿期患者的血清NPY值;规范医生对乙型肝炎肝硬化患者的辨证结果,分别选取代偿期与失代偿期中出现频次高的前5个证候并比较不同证候间的血清NPY值。运用SPSS18.0统计软件包进行统计分析。[结果]代偿期和失代偿期乙型肝炎肝硬化患者血清NPY水平的分别为119.135 0、72.860 0,且差异有统计学意义(P<0.05)。血清NPY水平在代偿期各证型之间差异有统计学意义,且肝郁脾虚组>气滞血瘀组>湿热蕴结组>肝肾阴虚组>肝气郁结组;在失代偿期五组之间差异无统计学意义。[结论]血清NPY水平与疾病的进展有关,与代偿期乙型肝炎肝硬化的中医证型有关。[Objective] To investigate the hepatitis B patients with cirrhosis of traditional Chinese medicine （TCM） syndrome and the correlation of serum NPY levels. [Methods] Compare compensation period and decompensation period in patients with serum NPY value. Doctor specification of syndrome differentiation in patients with hepatitis B cirrhosis of the liver as a result, the compensation period and decompensation period appear respectively selected high frequency of the first five syndromes and compare the value of serum NPY between different syndrome. Using the SPSS18.0 statistical software package for statistical analysis. [Results] Compensation period and decompensation period NPY levels in the serum of patients with hepatitis B cirrhosis of the liver were 119.135 0, 72.910 0, and the difference was statistically significant （P 〈 0.05）. Serum NPY level in compensatory phase difference was statistically significant among different syndrome types, and stagnation of liver Qi and spleen deficiency group 〉 Qi and blood stasis group 〉 damp and hot accumulate knot 〉 liver-kidney Yin deficiency group 〉 move within group. In decompensated period there was no statistically significant difference between groups of five. [Conclusion] Serum NPY levels associated with disease progression, and the compensatory phase of hepatitis B cirrhosis related to the TCM syndrome type.

关 键 词：乙型肝炎肝硬化 中医证型 单一证候 血清NPY 

分 类 号：R575.2[医药卫生—消化系统]