表皮生长因子与干燥综合征伴发萎缩性舌炎的相关性研究  

Study on the correlation of epidermal growth factor and Sjgren's syndrome with atrophic glossitis

作　　者：袁昌青[1] 曹颖秀[2] 刘斌[3] 董静[3] 邓婧[1] 耿国梁[1] 

机构地区：[1]青岛大学附属医院口腔科,山东青岛266003 [2]德州市人民医院口腔科,山东德州253014 [3]青岛大学附属医院风湿免疫科,山东青岛266003

出　　处：《上海口腔医学》2014年第6期731-735,共5页Shanghai Journal of Stomatology

摘　　要：目的 :探讨表皮生长因子(epidermal growth factor,EGF)及其受体(EGF receptor,EGFR)与干燥综合征(Sjgren’s syndromes,SS)伴发萎缩性舌炎(atrophic glossitis,AG)的相关性及可能的作用机制。方法:干燥综合征患者按未伴发与伴发轻、中、重度萎缩性舌炎分为4组,健康成年人为对照组,应用ELISA法检测唾液中的EGF含量,SP免疫组化技术检测舌上皮细胞中EGFR的表达情况,采用SPSS19.0软件包进行统计学处理。结果:干燥综合征未伴发及伴发萎缩性舌炎组唾液EGF浓度均显著低于正常对照组(P<0.01),2组之间差异显著(P=0.024),干燥综合征伴发轻、中、重萎缩性舌炎组唾液EGF水平逐渐降低,两两比较差异显著(P<0.05);干燥综合征伴发中、重度萎缩性舌炎组舌上皮细胞EGFR表达较正常对照组显著降低(P=0.009,P=0.037),其余2组与对照组之间差异无显著性;舌背黏膜萎缩程度与唾液EGF水平显著相关(r=-0.673,P<0.01)。结论:干燥综合征患者唾液中表皮生长因子浓度明显降低,且与其伴发萎缩性舌炎有密切相关性。PURPOSE： To investigate the correlation between epidermal growth factor （EFG） and atrophic glossitis （AG） in patients with Sjogren＇s syndromes （SS） and explore its pathogenesis. METHODS： Ninety-three patients with SS （60 with AG and 33 without AG） and 20 normal were selected. The concentrations of EGF in saliva were analyzed by ELISA. The expressions of EGF receptor （EGFR） in the epithelial cells of the tongue were assayed by immunohistochemistry. The differences among each group were analyzed with SPSS19.0 software package. RESULTS： The saliva EGF concentrations in SS was lower than that in normal control group （P〈0.0001）,and EGF concentrations in SS with AG was significantly lower than that in SS without AG （P=0.024）. EGF levels in saliva gradually decreased in the mild, moderate and severe atrophic glossitis groups, and there were significant differences among each group（P〈0.05）. EGFR in the epithelial cells of tongue was lower in SS with moderate and severe AG than in the control group （P=0.009, P=0.037）, and there was a significant correlation between EGF and the degree of AG （r=-0.673, P〈0.01）. CONCLUSIONS： Saliva EGF concentrations decrease significantly in patients with SS and it is closely related to the morbidity of atrophic glossitis.

关 键 词：干燥综合征 萎缩性舌炎 表皮生长因子 表皮生长因子受体 

分 类 号：R781.57[医药卫生—口腔医学]